颈动脉粥样硬化与脑梗死相关性研究

目的通过对颈动脉粥样硬化的检测及治疗，探讨其与脑梗死的相关性。方法以200例脑梗死组及200例非脑血管病组为研究对象，检测颈动脉内膜一中膜厚度、颈动脉粥样硬化斑块、颈动脉狭窄程度；将非脑血管病组有颈动脉粥样硬化斑块的患者随机分成两组，一组用阿司匹林及辛伐他汀（治疗组）治疗，另一组单用阿司匹林（对照组）治疗，1年后复查颈部血管超声，对比治疗前后的颈动脉粥样硬化斑块的大小，同时观察1年中两组干预治疗的患者缺血性脑血管病的发生率，并进行比较。结果颈动脉斑块发生率在脑梗死组为70％，非脑血管病组为28％；颈动脉中重度狭窄发生率在脑梗死组22％，非脑血管病组为6％，脑梗死组颈动脉内膜一中膜厚度、颈动脉粥样硬化斑块、颈动脉狭窄发生率与非脑血管病组相比差异有显著性（P〈0．01；P〈0．01；P〈0．01）；经干预治疗后在治疗组中颈动脉粥样硬化斑块有不同程度的缩小，内部回声增强；对照组中粥样硬化斑块大小变化不明显；1年中治疗组中脑梗死的发生率为8．7％（2／23），对照组为37．5％（9／24），两组相比差异有显著性（P〈0．05）结论颈动脉粥样硬化斑块与脑梗死的发病关系密切，对其进行干预性治疗可减少脑梗死的发生。

The Relationship Between Carotid Atherosclerosis and Cerebral Infarction

Objective To explore the correlation between carotid atherosclerosis and cerebral infarction through checking carotid atherosclerosis.Methods Intima-media thickness of carotid arterial,carotid atherosclerosis plaque score and degree of stenosis are measured in both infarction groups(200 cases)and control group(200 cases).Patients with carotid atherosclerosis plaque were treated with aspirin and siavaastatin and then the plaque after theray was compared with itself before theray in size of plaque and degree of sclerosis.Resluts The incidence rate of carotid atherosclerosis plaque is 70% in infarction group and 28% in control group;The incidence rate of moderate-severe carotid stenosis is 22% in infarction group and 6% in control group.The difference between infarction and control group is significant in intima-media thickness of carotid arterial,size of carotid atherosclerosis plaque and level of stenosis(P<0.01,P<0.01,P<0.01.);After treating the size of plague and degree of sclerosis in treated group are reduced.The incidence rate of cerebral infarction is 8.7% in trented group and 37.5% in control group,which is significantly different.Conclusions Carotid atherosclerosis plaque is related with onset of cerebral infarction significantly.Treatment aiming to the plaque can decrease incidence rate of cerebral infarction.