中国南海海绵Cinachyrella australiensis 化学成分研究

目的:研究中国南海海绵Cinachyrella australiensis的化学成分.方法: 用多种色谱技术进行分离纯化,根据理化性质和波谱数据进行结构鉴定. 结果:从中国南海海绵C. australiensis中分离得到19个化合物,分别为2 -甲氧基-6,12,15-三烯-8-炔-十八酸(1),邻苯二甲酸二正丁基酯(2),邻苯二甲酸二-(2-乙基)-己基酯(3),(-)(3S)-1,2,3,4-四氢-β-咔啉-3-羧酸(4),L-色氨酸(5),对羟基苯甲醛(6),对羟基苯乙醇(7),对羟基苯丙醇(8), 胆甾-4-烯-3-醇(9),2-甲基-6-氨基嘌呤脱氧核苷(10),6-氨基嘌呤脱氧核苷(11),6-氨基嘌呤核苷(12),尿嘧啶(13),胸腺嘧啶(14),胸腺嘧啶脱氧核苷(15),尿嘧啶脱氧核苷(16),乙基-α-脱氧核糖苷(17),异光黄素(18),zarzissine(19). 结论:1和18为新化合物,化合物2～17,19系首次从该种中分离得到.

Chemical constituents from chinese marine sponge Cinachyrella australiensis

OBJECTIVE: To investigate the secondary metabolites from Chinese marine Sponge Cinachyrella australiensis. METHODS: Column chromatography techniques including HPLC were used for the separation and purification of the compounds, and extensive spectral analyses including various 2D NMR spectra were employed for structure elucidation. RESULTS: Nineteen compounds were obtained,including 2-methyoxy-6,12,15-trien-8-yne-octadecanoic acid (1), 2-benzenedicarboxylic acid dibutyl ester(2), 1,2-benzenedicarboxylic acid bis(2-ethylhexyl)ester(3), (-) (3S)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid(4), L-Tryptophan (5), p-hydroxylbenzaldehyde (6), p-hydroxyl-benzylethanol(7), p-hydroxyl-benzyl-propanol(8), cholesta-4-en-3-ol(9), 2-methyl-6-amino-9-(2-deoxy-beta-D- ribofuranosyl-purine(10), 2'-Deoxyadenosine (11), 6-amino-9-beta-D-ribofuranosyl-9H-purine (12),uracil(13), thymine(14), thymidine(15), 1-(2-deoxy-beta-D-Ribofuranosyl) uracil(16), 1-ethyl-alpha-(2-deoxy)-beta-D-ribofuranos(17),isolumichrome(18),and zarzissine(19). CONCLUSION: Compounds 1 and 18 are new natural products,and compounds 2 to 17 as well as 19 are isolated from this species for the first time.