| 有机锡化合物对S-180和胃癌细胞的影响 |
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| 引用本文： | 崔景荣,朱立红,肖军军,孙梅.有机锡化合物对S-180和胃癌细胞的影响[J].北京大学学报(医学版),1993(1). |
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| 作者姓名： | 崔景荣 朱立红 肖军军 孙梅 |
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| 作者单位： | 北京医科大学药学院生化药理研究室，北京医科大学药学院生化药理研究室，北京医科大学细胞生物学教研室，北京医科大学细胞生物学教研室 药学专业85级学生，基础医学专业87级学生 |
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| 摘 要： | 有机锡化合物(Et_2SnCl_2phen)是类似于顺铂结构的新型抗癌物质。实验结果表明,Et_2SnCl_2phen对S-180细胞生长有明显的抑制作用,阻止G_2+M→G_1期的进行,造成G_2+M期细胞堆集。Et_2SnCl_2phen与胃癌作用后,扫描电镜观察表明,粘着在裸露的玻璃表面的癌细胞变为球形,膜皱襞,微绒毛减少。可使S-180和人胃癌细胞的DNA相对含量明显减少。
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| 关 键 词： | 有机锡化合物 S-180细胞 人胃癌细胞 流式细胞光度计 DNA |
EFFECT OF THE ORGANOTIN COMPOUND ON THE S-180 AND GASTRIC CANCER CEII |
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| Cui Jingrong Laboratory of Research of Biochemical Pharmacology.EFFECT OF THE ORGANOTIN COMPOUND ON THE S-180 AND GASTRIC CANCER CEII[J].Journal of Peking University:Health Sciences,1993(1). |
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| Authors: | Cui Jingrong Laboratory of Research of Biochemical Pharmacology |
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| Institution: | Cui Jingrong Laboratory of Research of Biochemical Pharmacology |
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| Abstract: | The effect of Et_2 SnCl_2 phen on mouse S-180 sarcoma cells and human gastric cancer cells was stu-died by analysing cell cycle, and determining DNA content of the cells. The surface of cancer cells wasobserved under scanning electron microscope. |
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| Keywords: | Flow cytometry Et_2SnCl_2phen S-180 sarcoma cells Human gastric cancer cells Content of DNA |
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