| 巨噬细胞膜变形性与细胞骨架微丝关系的研究 |
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| 引用本文： | 戴建武,董群,苏雅娴,尚彤.巨噬细胞膜变形性与细胞骨架微丝关系的研究[J].北京大学学报(医学版),1992(2). |
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| 作者姓名： | 戴建武 董群 苏雅娴 尚彤 |
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| 作者单位： | 北京医科大学细胞生物学教研室
(戴建武，董群，苏雅娴)，北京医科大学分析计算中心(尚彤) |
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| 摘 要： | 以巨噬细胞的圆形因子和面积作为细胞膜变形性指标,研究细胞膜变形性与膜下微丝的关系。结果表明,ConA能使细胞膜变形性增大,同时加入细胞松弛素B则膜变形性下降。本实验将图像分析技术和多元统计软件包结合,为定量研究活细胞行为的一个成功尝试。
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| 关 键 词： | 变形性 巨噬细胞 微丝 图像分析 |
THE RELATIONSHIP BETWEEN THE DEFORMABILITY OF MACROPHAGE MEMBRANES AND CYTOSKELETONS |
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| Dai Jianwu,et al.THE RELATIONSHIP BETWEEN THE DEFORMABILITY OF MACROPHAGE MEMBRANES AND CYTOSKELETONS[J].Journal of Peking University:Health Sciences,1992(2). |
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| Authors: | Dai Jianwu |
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| Institution: | Dai Jianwu,et al Department of Cell Biology |
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| Abstract: | Image Analysis and Multivariate Analysis were used to study the deformability of macrophagemembranes before and after ConA combined with membrane receptors. In addition, we also studiedthe membrane deformability when F-actin was destroyed by cytochalasin B. It was found that the me-mbrane deformability increased after ConA binding. However, adding both ConA and cytochalasin Bcould decrease the deformability. In our experiment, Image Analysis was successfully used to study thebehavior of living cells quantitatively. |
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| Keywords: | Deformability Macrophage membrane Microfilament Image analysis |
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