高血压患者糖代谢状况调查及筛查结果分析

目的:获得原发性高血压患者伴有糖代谢异常的流行病学数据,为全面干预危险因素提供科学的分析依据.方法:采用流行病学横断面调查方法,对全国5个中心的心内科门诊就诊不知晓自患糖尿病的高血压患者进行糖代谢状况的问卷调查和现场血糖测定.结果:同时对1 421例患者进行空腹血糖(fasting blood sugar, FBS)和口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)2小时血糖的测定,其中326人(22.9%)达到了糖尿病诊断标准.符合血糖调节异常者915人(64.4%).原发性高血压合并糖尿病患者与无糖尿病患者相比,收缩压水平、腰围、腰臀比和血浆甘油三酯水平更高.结论:原发性高血压患者合并糖耐量异常的比例非常高,而日常诊断率却很低.对于合并代谢综合征的高血压患者,更应关注糖代谢情况,积极进行OGTT,早期发现和治疗糖代谢紊乱.

Investigation and screening of glucose metabolism in essential hypertension patients without diagnosed diabetes mellitus

Objective:To obtain the glucometabolic profile of patients with essential hypertension in China. Methods:This is an epidemiologic cross-sectional survey and screening study, 5 sites in China participated in. Patients with essential hypertension and without known diabetes mellitus(DM) answered the questionnaire and received in-site fasting blood glucose (FBG) determination and simple oral glucose tolerance test (OGTT). Results: A total of 1 421 patients had the data of FBG and OGTT 2-hour glucose. Among them, The prevalence rates of newly diagnosed DM and impaired glucose regulation (IGR) were 22.9% and 64.4% respectively. Patients with newly diagnosed DM have higher systolic blood pressure , waistline , waist-to-hip ratio and plasma triglyceride. Conclusion:Newly diagnosed disturbed glucometabolic status is common among patients with essential hypertension without DM history, which had very low diagnose rate in routine work. We must pay more attention to the glucometabolic status of patients with hypertension, especially the one with metabolic syndrome , OGTT should be as a routine procedure in the diagnosis of such patients.