| 神经干细胞移植治疗遗传性小脑萎缩的临床研究 |
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| 引用本文： | 田增民,陈涛,Nanbert ZHONG,李志超,尹丰,刘爽.神经干细胞移植治疗遗传性小脑萎缩的临床研究[J].北京大学学报(医学版),2009,41(4). |
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| 作者姓名： | 田增民 陈涛 Nanbert ZHONG 李志超 尹丰 刘爽 |
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| 作者单位： | 海军总医院全军神经外科中心,北京,100048;北京大学基础医学院医学遗传学系 |
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| 摘 要： |
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| 关 键 词： | 橄榄体桥脑小脑萎缩 干细胞移植 治疗结果 |
Clinical study of transplantation of neural stem cells in therapy of inherited cerebellar atrophy |
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| Zeng-min TIAN,Tao CHEN,Nanbert ZHONG,Zhi-chao LI,Feng YIN,Shuang LIU.Clinical study of transplantation of neural stem cells in therapy of inherited cerebellar atrophy[J].Journal of Peking University:Health Sciences,2009,41(4). |
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| Authors: | Zeng-min TIAN Tao CHEN Nanbert ZHONG Zhi-chao LI Feng YIN Shuang LIU |
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| Abstract: | Objective:To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA). Methods: The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and expanded in vitro. The cultured neurospheres were then implanted into the dentate nuclei of patients by stereo tactic operation. Totally, 12 patients (7 males and 5 females with age ranging 22-62 years, mean 43 years) were treated by this operation from August 2006 to August 2008. Results: The cells of fetal cerebellum were expanded by 107folds in undifferentiated state in the culture. After the operation, no rejection was detected. Follow up, the effective rates were 58. 3% after 3 months, 75.0% after 6 months, and 66.7% for 12-24 months (mean 18 months). Conclusion: the transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA, but the long term effectiveness need to be taken in consideration. |
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| Keywords: | Olivopontocerebellar atrophies Stem cell transplantation Treatment outcomes |
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