高容量血液滤过在多器官功能障碍综合征患者中临床应用评价 |
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引用本文: | 张殿红,刘兆润,唐利平,杨辉,陈汉敏.高容量血液滤过在多器官功能障碍综合征患者中临床应用评价[J].中国冶金工业医学杂志,2010,27(5):497-499. |
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作者姓名: | 张殿红 刘兆润 唐利平 杨辉 陈汉敏 |
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作者单位: | 中国医科大学第八临床学院鞍钢总医院,辽宁鞍山,114002 |
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摘 要: | 目的:观察高容量血液滤过(HVHF)对多器官功能障碍综合征(MODS)患者炎症介质的清除作用,探讨HVHF对MODS患者的治疗效果。方法:19例MODS患者随机分为两组,HVHF治疗组10例,连续性静脉-静脉血液滤过(CVVH)治疗组9例;用酶联免疫吸附法(ELISA)测定HVHF和CVVH治疗前和治疗后患者血清中肿瘤坏死因子-α(TNFα)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平,并观察两组患者的死亡率和血浆尿素氮(BUN)、肌酐(Scr)值的变化。结果:HVHF和CVVH治疗后,患者血浆中BUN、Scr均降低(P〈0.05),两组患者治疗后与治疗前相比血清TNFα、IL-6、IL-8水平均有下降(P〈0.05);与CVVH治疗组相比,HVHF治疗组患者血清中TNFα、IL-6、IL-8下降更为明显(P〈0.05)。结论:HVHF治疗能明显增加MODS患者血清中TNFα、IL-6、IL-8的清除能力,改善MODS患者的预后。
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关 键 词: | 高容量血液滤过 多器官功能障碍综合征 细胞因子 |
The clinical application of high-volume hemofiltration in the patients with multiple organ dysfunction syndrome |
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Institution: | ZHANG Dian-hong,LIU Zhao-run,TANG Li-ping,et al.ICU,General Hospitaol of Anshan Irion & Steel Complex.Anshan 114002 |
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Abstract: | Objective:To observe the effects of high-volume hemofiltration(HVHF)on the cytokines in the patients with multiple organ dysfunction syndrome and to investigate the therapitic action of HVHF for the patients with MODS.Methods:19 patients with multiple organ dysfunction syndrome were randomly divided into HVHF group(n=10)and CVVH group(n=9),the levels of serum tumor necrosis factor-α(TNF-α),interleckin-6(IL-6)and interleckin-8(IL-8)were measured by enzyme-linker immunoadsorbent assay(ELISA)before and after the therapy,and to observe the death rates and the levels of BUN and Scr.Results:Compared with that before the therapy,the average concentrations of plasma creatinine and urea were decreased significantly after HVHF or CVVH(P0.05).The level of TNF α,IL-6,IL-8 in two groups all decreased after HVHF or CVVH(P0.05);Compared with CVVH group,the level of TNF α,IL-6,IL-8 after the HVHF curing were lower(P0.05).Conclusions:HVHF could decrease the levels of inflammatory mediator in the patients with MODS,and improve the survival rate of MODS patients. |
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Keywords: | High-volume hemofiltration Multiple organ dys-function syndrome Cytokine |
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