丹芎瘢痕涂膜的临床应用研究

目的:本文通过769例病人应用丹芎瘢痕涂膜防治瘢痕增生的治疗效果,为烧烫伤后瘢痕增生提供一种新的治疗手段.方法:我们根据中医、中药活血化淤原理,经多年临床实践研制而成的丹芎瘢痕涂膜,由丹参、川芎等复方组成.药物使用,将丹芎瘢痕涂膜直接均匀涂于瘢痕表面上,形成药膜,次日揭去药膜,重新涂药,每日1次,连续用药5个月.疤痕止痒软化膏对照,每日1次,连续用药5个月.结果:(1)创面愈合后瘢痕刚开始增生者,丹芎瘢痕涂膜治疗组共415例,显效77例,有效323例,总有效率96.39%;疤痕止痒软化膏同体对照组51例,显效0例,有效20例,总有效率39.22%,治疗组显著优于对照组.(2)创面愈合后瘢痕已增生者,丹芎瘢痕涂膜治疗组354例,显效88例,有效257例,总有效率97.46%;疤痕止痒软化膏对照组63例,显效4例,有效34例,总有效率60.32%,治疗组显著优于对照组.(3)丹芎瘢痕涂膜治疗组与疤痕止痒软化膏对照组综合疗效比较,丹芎瘢痕涂膜治疗组769例,显效165例,有效580例,总有效率96.88%;疤痕止痒软化膏对照组114例,显效4例,有效54例,总有效率50.88%,治疗组显著优于对照组.(4)60例丹芎瘢痕涂膜治疗组与同体空白对照组比较,治疗组显效25例,有效34例,总有效率98.33%;对照组显效0例,有效11例,总有效率18.33%;治疗组显著优于对照组.(5)未发现不良反应.结论:经769例病人临床应用丹芎瘢痕涂膜,并与已知疤痕止痒软化膏比较,丹芎瘢痕涂膜治疗效果显著优于疤痕止痒软化膏,丹芎瘢痕涂膜是一种安全、有效、新的创面瘢痕外用药.

The study of Danxiong Scar Coating in the clinical application to prevent scar proliferation

Objective:To test the effect of Danxiong Scar Coating to prevent scar proliferation.Methods:769 cases were enrolled in the research.Danxiong Scar Coating was used for research group on the scar surface to form drug membrane,uncover the membrane the next day and embrocate again,once a day for 5 months continuously.Scar tickle-relieving ointment was used for control group once a day,and continuously for 5 months.Results:(1)The patients without scar proliferation after the healing of the wounding surface in Danxiong Scar Coating treating group is 415 cases,77 cases are clearly effective,323 cases are effective,the total effective rate is 96.39%;in Scar tickle-relieving ointment autocontrol treating group is 51 cases,0 case are clearly effective,20 cases are effective,the total effective rate is 39.22%;(2)The patients with scar proliferation after the healing of the wounding surface in Danxing Scar Coating treating group is 354 cases,88 cases are clearly effective,257 cases are effective,the total effective rate is 97.46%;in Scar tickle-relieving ointement treating group is 63 cases,4 cases are clearly effective,34 cases are effective,the total effective rate is 60.32%;(3)The comparison of comprehensive effect between Danxiong Scar Coating treating group and Scar tickle-relieving ointment treating group,in the 769 cases treated by Danxiong Scar Coaing,165 cases are clearly effective,580 cases are effective,the total effective rate is 96.88%;in the 114 cases treated by Scar tickle-relieving ointment for control,4 cases are clearly effective,54 cases are effective,the total effective rate is 50.88%;(4)Comparison in 60 cases between the group cured by Danxiong Scar Coating and the blank autocontrol group,in the curing group 25 cases are clearly effective,34 cases are effective,the total effective rate is 98.33%;in the control group 0 case are clearly effective,11 cases are effective,the total effective rate is 18.33%;(5)No adverse effect occurs.In research group.Conclusions:The curative effect of Danxiong Scar Coating is obviously better than that of scar tickle-relieving ointment,It is a new kind of drug for external application,which is safe and effective for the scar of wounding surface.