| 阿德福韦酯对HBeAg阳性慢性乙型肝炎患者外周血T细胞亚群的影响 |
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| 引用本文： | 董莉,李军,韩亚萍,刘源,宋培新,郭小芙.阿德福韦酯对HBeAg阳性慢性乙型肝炎患者外周血T细胞亚群的影响[J].苏州大学学报(自然科学版),2008,28(6):962-965. |
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| 作者姓名： | 董莉 李军 韩亚萍 刘源 宋培新 郭小芙 |
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| 作者单位： | 南京医科大学第一附属医院,感染病科,江苏南京,210029 |
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| 基金项目： | 国家自然科学基金，江苏省135人才基金 |
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| 摘 要： | 目的 探讨阿德福韦酯(ADV-dpv)抗病毒治疗对HBeAg阳性慢性乙型肝炎患者外周血T细胞亚群的影响.方法 选择57例HBeAg阳性慢性乙型肝炎患者,均给予ADV-dpv 10 mg,每日1次,共48周,采用流式细胞术检测治疗前、治疗3个月和6个月患者外周血T细胞亚群.结果 在抗病毒治疗前,与低病毒载量患者相比,高病毒载量患者存在着更为明显的T细胞亚群的失衡,差异有统计学意义(P<0.05);随着抗病毒治疗的进行,T细胞亚群失衡呈进行性改善,除CD3+T淋巴细胞较治疗前明显提高,差异有统计学意义(P<0.05)外,其余指标与治疗前比较,差异均无统计学意义(P>0.05);ADV-dpv治疗后HBV-DNA转阴组与未转阴组患者初始T细胞亚群的差异均无统计学意义(P>0.05).结论 HBeAg阳性慢性乙型肝炎患者的病毒载量与其外周血T细胞亚群的状态密切相关,经ADV-dpv抗病毒治疗后其外周血T细胞亚群的状态呈逐渐改善趋势.
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| 关 键 词： | 阿德福韦酯 HBeAg阳性慢性乙型肝炎 T淋巴细胞亚群 |
The Effect of Adefovir Dipivoxil on T Lymphocyte Subsetes in Patients with HBeAg-positive Chronic Hepatitis B |
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| DONG Li,LI Jun,HAN Ya-ping,LIU Yuan,SONG Pei-xin,GUO Xiao-fu.The Effect of Adefovir Dipivoxil on T Lymphocyte Subsetes in Patients with HBeAg-positive Chronic Hepatitis B[J].Suzhou University Journal of Medical Science,2008,28(6):962-965. |
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| Authors: | DONG Li LI Jun HAN Ya-ping LIU Yuan SONG Pei-xin GUO Xiao-fu |
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| Institution: | DONG Li,LI Jun,HAN Ya-ping,LIU Yuan,SONG Pei-xin,GUO Xiao-fu(Dept of Infection,the First Hospital Affiliated to Nanjing Medical University,Jiangsu Nanjing 210029,China) |
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| Abstract: | Objective To observe the effect of adefovir dipivoxil on T lymphocyte subsetes the treatment of HBeAg-positive chronic hepatitis B.Methods Totally 57 patients with HBeAg-positive chronic hepatitis B were treated with adefovir dipivoxil 10 mg/d for 48 weeks.The T lymphocyte subset in peripheral blood was analyzed by FCM before and after treatment for 3 and 6 months.Results The inferior T lymphocyte subsetes in peripheral blood correlated with the high level of pretreatment HBV-DNA(>107copies/ml)(P<0.05).CD3+... |
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| Keywords: | adefovir dipivoxil HBeAg-positive chronic hepatitis B T lymphocyte subset |
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