| 2型糖尿病患者血和尿中t-PA、PAI-1的变化及其临床意义 |
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| 引用本文： | 沈蕾,卢国元,谢燕,王兆钺.2型糖尿病患者血和尿中t-PA、PAI-1的变化及其临床意义[J].苏州大学学报(自然科学版),2005,25(5):857-859. |
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| 作者姓名： | 沈蕾 卢国元 谢燕 王兆钺 |
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| 作者单位： | 苏州大学附属第一医院肾内科,江苏苏州215006 |
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| 摘 要： | 目的探讨2型糖尿病患者血和尿t-PA及PAI-1浓度的变化，了解它们在糖尿病血管病变中的变化及其临床意义。方法根据尿白蛋白排泄率（UAER）将37例2型糖尿病患者分为两组：正常白蛋白尿组（DM）17例，微量白蛋白尿组（DN）20例。另取正常键康者20例作为对照组。用ELISA法分别检测3组的血浆和尿液t—PA及PAI-1浓度。结果尿液中t-PA浓度在正常白蛋白尿组低于正常对照组（P〈0．05）；微量白蛋白尿组明显低于正常对照组（P〈0．01）。结论尿液中t-PA浓度较血浆浓度更能反映中糖尿病的肾脏血管病变。
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| 关 键 词： | 2型糖尿病 t-PA PAI-1 |
| 文章编号： | 1673-0399(2005)05-0857-03 |
| 收稿时间： | 2005-03-11 |
| 修稿时间： | 2005年3月11日 |
Alterations of Plasma and Uric t-PA and PAI-1 in Type 2 Diabetes Mellitus |
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| Shen Lei;Lu GuoYuan;Xie Yan;Wang ZhaoYue.Alterations of Plasma and Uric t-PA and PAI-1 in Type 2 Diabetes Mellitus[J].Suzhou University Journal of Medical Science,2005,25(5):857-859. |
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| Authors: | Shen Lei;Lu GuoYuan;Xie Yan;Wang ZhaoYue |
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| Abstract: | Objective To measure the plasma and urine levels of t-PA and PAI-1 in type 2 diabetes mellitus and to study their clinical significance.Method Thirty seven patients with 2DM were divided into two groups on the basis of their urinary albumin excretion rate(UAER): nomalalbuminuria(DM,17),microalbuminuria(DN,20).ELISA method was used to detect the plasma and urine levels of t-PA and PAI-1.Result The urine levels of t-PA were lower in DM than in the control group(P<0.05).The urine levels of t-PA in DN were significant lower than that in the control group(P<(0.01)).Conclusion The levels of t-PA in urine are more sensitive to reflect the condition of 2DM than those in plasma. |
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| Keywords: | type 2 diabetes mellitus t-PA PAI-1 |
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