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脂联素、IL-6与2型糖尿病胰岛素抵抗及大血管病变的关系
引用本文:施毕旻,成兴波.脂联素、IL-6与2型糖尿病胰岛素抵抗及大血管病变的关系[J].苏州大学学报(自然科学版),2006,26(1):73-75.
作者姓名:施毕旻  成兴波
作者单位:苏州大学附属第一医院内分泌科,江苏苏州215006
摘    要:目的研究2型糖尿病患者药物干预前后与胰岛素抵抗有关的脂联素和炎症因子IL-6水平的变化,以及与大血管并发症之间的关系。方法采用ELISA检测14名正常人(对照组)、24例2型糖尿病非肥胖和16例肥胖糖尿病患者的血清脂联素、IL-6水平.计算其件前指数(BMI)、胰岛素抵抗指数(HOMA-IR).检测颈动脉内膜中层厚度(IMT),予胰岛素增敏剂噻唑烷二酮类(文迪雅)进行药物干预,并对部分指标进行相关性分析。结果糖尿病组尤其是肥胖组,存在更严重的胰岛素抵抗和低脂联素血症,而IL-6水平明显增高(P〈0.01)。脂联素水平与HOMA—IR、BMI、IL-6、IMT成负相关。而IL-6与HOMA-IR、BMI、IMT成正相关。药物干预后.胰岛索抵抗、脂联素和IL-6水平均有明显改善,特别在肥胖组(P〈0.05、P〈0.01)。结论低脂联素与肥胖、胰岛素抵抗和大血管病变密切相关,IL-6参与糖尿病特别是肥胖患者胰岛素抵抗的发生。噻唑烷二酮类药物在增加胰岛素敏感性的同时,还具有潜在的抗炎、抗动脉粥样硬化和免疫调节作用。

关 键 词:2型糖尿病  脂联素  胰岛素抵抗指数
文章编号:1673-0399(2006)01-0073-03
收稿时间:2005-06-14
修稿时间:2005年6月14日

The Correlation of Adiponectin, IL-6 with Insulin Resistance and Macrovascular Lesion in Type 2 Diabetes
SHI Bi-min,CHENG Xing-bo.The Correlation of Adiponectin, IL-6 with Insulin Resistance and Macrovascular Lesion in Type 2 Diabetes[J].Suzhou University Journal of Medical Science,2006,26(1):73-75.
Authors:SHI Bi-min  CHENG Xing-bo
Institution:Dept of Endocrinology, the First Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215006, China
Abstract:Objective To investigate the serum level changes of adiponectin and IL-6 and their relation with macrovascular complications in patients with type 2 diabetes before and after thiazolidinediones intervention.Methods Serum adiponectin and IL-6 level were examined using ELISA method in 16 patients with obese type 2 diabetes,24 patients with diabetes with normal body weight,and 14 controls.Their body mass index(BMI) and HOMA-IR were calculated and the internal membrane thickness(IMT) of carotid artery was also observed.These indexes were reexamined after thiazolidinediones(Avandia) intervention and correlation analysis was performed.Results A decreased serum concentration of adipidonectin and an elevated level of IL-6 and HOMA-IR were found in diabetes group especially in those with obesity(P<0.01).Serum adiponectin was negatively correlated with HOMA-IR,BMI,IL-6 and IMT while IL-6 was positively correlated with the above-mentioned indexes.After treatment with thiazolidinediones,the insulin resistance state and adponection and IL-6 were significantly improved especially in those with obesity(P<0.05,P<0.01).Conclusion Adiponectin is closed correlated with obesity,insulin resistance and macrovascular lesions.IL-6 may be involved in the mechanism of insulin resistance in type 2 diabetes patients especially in the obese diabetes group.In addition to enhance the sensitivity of insulin,thiazolidinediones may play a potential role in anti-inflammation,anti-atherosclerosis and immuno-regulation.
Keywords:IL-6
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