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胃癌中P-糖蛋白和C-erbB-2的表达及其相关性研究
引用本文:蔡颖,冯一中,张熔熔,唐威.胃癌中P-糖蛋白和C-erbB-2的表达及其相关性研究[J].苏州大学学报(自然科学版),2005,25(2):281-283.
作者姓名:蔡颖  冯一中  张熔熔  唐威
作者单位:苏州大学附属第二医院病理科,苏州大学附属第二医院病理科,无锡市第二人民医院病理科,无锡市第二人民医院病理科 江苏苏州215004 无锡市第二人民医院病理科,江苏无锡214002,江苏苏州215004,江苏无锡214002,江苏无锡214002
摘    要:目的 研究P- 糖蛋白(P -gp)和C- erbB- 2在胃癌组织中的表达及其相关性。方法 采用S P免疫组织化学染色法检测81例原发性胃癌P -gp和C- erbB -2的表达。结果 P gp的阳性率为5 0 .6 2 % (41/81) ,P- gp的表达与胃癌的组织学类型、浸润深度和淋巴结转移情况无关(P >0 .0 5 ) ,P -gp高表达率在C -erbB -2阳性组病例明显高于C -erbB -2阴性组病例(P <0 .0 5 )。结论 P -gp和C- erbB -2常协同表达于胃癌组织中,并可作为胃癌患者术后化疗的参考指标。

关 键 词:胃腺癌  P-糖蛋白  C-erbB-2  免疫组织化学
文章编号:1673-0399(2005)02-0281-03

Co-expression of P-glycoprotein and C-erbB-2 in Gastric Carcinoma
CAI Ying ,FENG Yi-zhong,ZHANG Rong-rong,et al.Co-expression of P-glycoprotein and C-erbB-2 in Gastric Carcinoma[J].Suzhou University Journal of Medical Science,2005,25(2):281-283.
Authors:CAI Ying    FENG Yi-zhong  ZHANG Rong-rong  
Institution:CAI Ying 1,2,FENG Yi-zhong1,ZHANG Rong-rong2,et al
Abstract:Objective To investigate the correlation of the co-expression of P-glycoprotein and C-erbB-2 in gastric carcinoma. Methods SP immunohistochemical staining technique was used to examine the expression of P-glycoprotein and C-erbB-2 in 81cases of gastric carcinoma samples. Results The high level expression of P-glycoprotein was not correlated with its histological grading, invasion depth and lymph node metastasis (P>0.05).P-gp expression was significantly higher in C-erbB-2 positive cases than in C-erbB-2-negative ones(P<0.05). Conclusion Coexpression of P-gp and C-erbB-2 is common in gastric cancer.Detection of P-gp and C-erbB-2 in such cases is helpful to make out chemotherapy regimen.
Keywords:stomach adenocarcinoma  P-glycoprotein  C-erbB-2  immunohistochemistry
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