Cockcroft-Gault方程和MDRD方程测定肾功能的临床应用

目的评估Cockcroft-Gault方程和MDRD方程计算肾小球滤过率来反应肾功能的可行性.方法测定147名患者的24小时肌酐清除率(24 h Ccr),同时测定血肌酐、尿肌酐、白蛋白、尿素氮并称体重.用Cockcroft-Gault方程(CG-GFR)和MDRD方程(MD-GFR分别以白人和黑人计算)估算肾小球滤过率,并进行比较分析.结果总体上,CG-GFR与24 h Ccr无差异,呈高相关(r=0.879).24 h Ccr分别与MD-GFR(白人)和MD-GFR(黑人)比较,差异有统计学意义.结论我国人群可以适用Cockcroft-Gault方程来评估肾功能,值得在临床上推广应用.MDRD方程可能不适用于中国人.

The Clinical Study of Feasibility of Using Cock-Gault Equation and MDRD Equation to Evaluate Renal Function

Objective To evaluate the feasibility of using Cockcroft-Gault formula(CG-GFR)and MDRD equation(MD-GFR) to estimate renal function. Methods Serum creatinine,urine creatinine, albumin and urea were determined in 147 patients, creatinine clearance rate calculated by 24 hour creatinine clearance rate and GFR estimated by Cockcroft-Gault formula and MDRD equation. Then the correlation between these groups was analyzed. Results There were no difference between 24 h Ccr and CG-GFR.There was significant difference between 24 h Ccr and MD-GFR (black people and white people). Conclusion Cockcroft-Gault equation can reflect Chinese renal function, but MDRD equation is not fit for Chinese.