| 对B型白血病病毒敏感的两种近交系小鼠血液生理和生化指标的比较 |
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| 引用本文： | 姜莹,丁隽,袁春萍,陈学进.对B型白血病病毒敏感的两种近交系小鼠血液生理和生化指标的比较[J].吉林医学,2009,30(11):969-971. |
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| 作者姓名： | 姜莹 丁隽 袁春萍 陈学进 |
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| 作者单位： | 上海交通大学医学院实验动物科学部,上海200025 |
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| 摘 要： | 目的：通过对FvB—Cre＋／一和FVB—ROSA转基因小鼠的血液生理和血液生化指标的测定和比较，为白血病模型动物的选择提供基础数据。方法：选取两种品系各10雌10雄56日龄小鼠，分别测定心率、血压，并采血进行血液生理和生化分析。结果：FVB—Cre＋／-和FVB—ROSA两种转基因小鼠的白细胞（WBC）、红细胞（RBC）、血红蛋白（nb）等各项生理指标及丙氨酸转氨酶（ALT）、门冬酸转氨酶（AST）、白蛋白（ALB）、碱性磷酸酶（AKP）、尿素氮（BUN）、总胆固醇（CHOL）等各项生化指标之间的差异均有统计学意义。结论：FVB—Cre＋／-和FVB—ROSA转基因小鼠在血液生理、生化数据上具有特点，可作为模型动物为白血病的治疗和研究提供支持。
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| 关 键 词： | 小鼠 白血病 FVB—Cre+/- FVB—ROSA |
Comparison of blood physiological and biochemical indexes in two kinds of inbred line mice which sensitive to type B leukemia virus |
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| Institution: | JIANG Ying, DING Juan, YUAN Chun - ping, et al ( Department of laboratory Animal Science, Medical College of Shanghai Jiaotong University, Shanghai 200025, China) |
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| Abstract: | Objective Through blood biochemical and blood physiological indicators measurement of the FVB-Cre+/-and FVB-ROSA transgenic mice and comparison of animal model for leukemia,to provide basic data selection.Method Two kinds of strains of 56-day -old mice(10 female,10 male) were measured of heart rate and blood pressure,and blood physiological and biochemical indicators were analyzed.Results In two kinds of FVB - Cre + / - and FVB - ROSA transgenic mice,leukocytes(WBC),red blood cell(RBC), hemoglobin(HB) and other physiological indicators,and alanine aminotransferase(ALT),aspartic acid aminotransferase(AST),albumin (ALB),alkaline phosphatase(AKP),blood urea nitrogen(BUN),total cholesterol(CHOL) and other biochemical parameters had significant difference.Conclusion The blood physiological and biochemical data in FVB - Cre + / - and FVB - ROSA transgenic mice have characteristics,and the test animals can as a model for leukemia treatment and research support. |
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| Keywords: | Mouse Leukemia FVB-Cre+/- FVB - ROSA |
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