降钙素原对新生儿感染性疾病诊断意义的探讨

目的:探讨血清降钙素原(procalcitonin,PCT)对新生儿感染性疾病诊断的意义。方法:将儿科92例患儿分成全身感染组、局部感染组和非感染组,用酶联荧光免疫技术测定其PCT值,并与CRP和WBC计数做比较。结果:全身感染组、局部感染组及非感染组PCT阳性率分别为93.10%、51.28%和16.66%;三组组间比较,差异有统计学意义(P<0.005)。以PCT≥2 ng/ml为临界值,PCT诊断新生儿全身严重的细菌感染性疾病的敏感度为75.86%,特异性为95.83%,优于CRP和WBC计数。结论:PCT对新生儿细菌感染性疾病诊断具有较高的敏感度和特异性,与CRP和WBC计数相比,对新生儿细菌感染引起全身性感染性疾病早期诊断优势明显。

Investigation of diagnostic value of procalcitonin(PCT) level of neonates with infectious disease

Objective To investigate the diagnostic value of procalcitonin(PTC)level of neonates with infectious disease.Methods To classify 92 cases of infantile into systematic infection group,local infection group and none infection group,use ELFA to deter mine their PCT values and compare them to the counts of CRP and WBC.Results The positive rates of PCT in systematic infection group,local infection group and none infection group are 93.10%,51.28% and 16.66% respectively;the difference are significant among the three groups(P<0.005).With PCT≥2 ng/ml as the critical value,the sensitivity of PCT to diagnose the whole body serious bacterial infectious disease of neonates is 75.86%,the specificity is 95.83%,which are better than the counts of CRP and WBC.Conclusion the sensitivity and specificity of PCT to diagnose the bacterial infectious disease of neonates are higher than those of CPR and WBC,which have an obvious advantage to diagnose the neonates’ systematic infectious disease caused by bacteria in an early stage.