| 脂蛋白相关磷脂酶A_2与冠心病患者血管内皮之间的关系 |
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| 引用本文： | 徐祥忠,徐丽娜,韩济南,张志军.脂蛋白相关磷脂酶A_2与冠心病患者血管内皮之间的关系[J].吉林医学,2005,26(12):1265-1266. |
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| 作者姓名： | 徐祥忠 徐丽娜 韩济南 张志军 |
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| 作者单位： | [1]梅河口市妇幼保健院,吉林梅河口135000 [2]吉林大学第一医院,吉林长春130021 |
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| 摘 要： | 目的:探讨血脂蛋白相关磷脂酶A2(LP-PLA2)与冠心病(CHD)患者血管内皮之间的关系。方法:检测CHD患者血LP-PLA2水平,同时检测内皮素(ET)、一氧化氮(NO)、内皮细胞因子范登伯因子(vonWillebrandfactor,vWF)及血浆凝血酶活化因子抑制剂-1(plasminogenactivatorinhibitor-1,PAI-1),探讨LP-PLA2对血管内皮功能的影响。结果:CHD组在vWF﹑PAI-1﹑负荷前后FMD差﹑ET﹑NO﹑LP-PLA2项目上均与对照组有显著性差异(P<0.05),相关检验显示LP-PLA2与NO呈线形负相关,与vWF呈线形正相关(P<0.05)。结论:LP-PLA2是CHD发病的危险因素,它可能通过损伤内皮细胞的功能增加患病风险。
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| 关 键 词： | LP-PLA_2 冠心病 内皮细胞功能 |
| 文章编号： | 1004-0412（2005）12-1265-02 |
| 收稿时间： | 2005-07-04 |
| 修稿时间： | 2005年9月26日 |
The relationship between the LP-PLA2 and the function of the endothelial cell in coronary heart disease |
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| XU Xiang-zhong, XU Li-no, HAN Ji-nan, et al.The relationship between the LP-PLA2 and the function of the endothelial cell in coronary heart disease[J].Jilin Medical Journal,2005,26(12):1265-1266. |
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| Authors: | XU Xiang-zhong XU Li-no HAN Ji-nan |
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| Institution: | 1. The Women and Children Health Care Hospital of Meihekou City, Meihekou 135000,China;2. The First Hospital of Jilin University, Chongchun 130021 China |
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| Abstract: | Objective To investigate the relationship between the LP-PLA2 and the endothelial cell in coronary heart disease(CHD)patients.Method Detect the level of LP-PLA2 in plasma,detect ET,NO,vWF,PAI-1 to investigate the effect on the function of the endothelial cell of blood vessel.Result The vWF,PAI-1,the FMD difference before and after load,ET,NO,LP-PLA2 in CHD group show statistical difference with control group(P<0.05),relationship test show that the LP-PLA2 is linar negative relation with NO and linar positive relation with vWF(P<0.05).Conclusion LP-PLA2 is the danger factor of CHD,it contribute to CHD through damaging the endothelial cell function mechanism. |
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| Keywords: | LP-PLA2 Coronary heart disease The function of the endothelial cell |
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