| 冰片增强5-羟色氨酸抗抑郁作用的研究 |
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| 引用本文： | 王榕乐,谭毓治,刘峰,胡华良.冰片增强5-羟色氨酸抗抑郁作用的研究[J].广东药学院学报,2007,23(5):550-552,555. |
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| 作者姓名： | 王榕乐 谭毓治 刘峰 胡华良 |
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| 作者单位： | 广东药学院,药理教研室,广东,广州,510006 |
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| 摘 要： | 目的研究冰片对5-羟色氨酸(5-HTP)抗抑郁作用的影响。方法采用小鼠悬尾试验、大鼠强迫游泳试验,以动物不动的失望时间为指标;采用利血平致小鼠抑郁模型,以眼睑下垂程度和体温为观察指标,评价冰片对5-羟色氨酸抗抑郁作用的影响。结果冰片可加强5-HTP缩短悬尾及强迫游泳试验中的失望时间;可增强5-HTP对抗由利血平所致的小鼠眼睑下垂和体温下降。结论冰片可增强5-HTP的抗抑郁作用。
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| 关 键 词： | 冰片 5-羟色氨酸 抑郁 悬尾试验 强迫游泳试验 眼睑下垂 |
| 文章编号： | 1006-8783（2007）05-0550-03 |
| 修稿时间： | 2007-06-252007-09-26 |
Study on the role of borneol in enhancing antidepressant effects of 5-hydroxytryptophane |
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| WANG Rong-le,TAN Yu-zhi,LIU Feng,HU Hua-liang.Study on the role of borneol in enhancing antidepressant effects of 5-hydroxytryptophane[J].Academic Journal of Guangdong College of Pharmacy,2007,23(5):550-552,555. |
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| Authors: | WANG Rong-le TAN Yu-zhi LIU Feng HU Hua-liang |
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| Institution: | Section of Pharmacology, Guangdong College of Pharmacy, Guangzhou 510006, China |
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| Abstract: | Objective To study the role of Borneol in enhancing antidepressant effects of 5-hydroxytryptophane(5-HTP).Methods Mouse tail suspension test,rat forced swimming test and reserpine-induced mouse depression model were used to evaluate the role of borneol in enhancing antidepressant effects of 5-hydroxytryptophane(5-HTP).Results Borneol significantly enhanced the effects of 5-HTP to shorten disappointment time in mouse tail suspension test and rat force swimming test and to antagonize the ptosis,hypothermia in mice induced by reserpine.Conclusion Borneol enhances antidepressant effects of 5-hydroxytryptophane. |
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| Keywords: | borneol 5-hydroxytryptophane depression tail suspension test rat force swimming test |
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