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利妥昔单抗致不良反应325例文献分析
引用本文:陈永,高永艳,李艳,梁志雄.利妥昔单抗致不良反应325例文献分析[J].广东药学院学报,2010,26(2):179-181.
作者姓名:陈永  高永艳  李艳  梁志雄
作者单位:1. 广东药学院,附属第一医院药剂科,广东,广州,510080
2. 广东省中医院,药剂科,广东,广州510120
3. 广东药学院,药科学院,广东,广州,510006
摘    要:目的探讨抗肿瘤靶向药物利妥昔单抗(美罗华)不良反应的特点及规律,为临床安全、合理用药提供参考。方法采用回顾性研究方法,利用中国期刊全文数据库对1999~2009年报道的利妥昔单抗不良反应病例进行统计分析。结果不良反应主要为输注反应,且主要出现于第1次静脉滴注。结论使用利妥昔单抗治疗应严密监护,保证用药安全。

关 键 词:利妥昔单抗  美罗华  不良反应

Literature analysis of 325 cases of adverse drug reactions of rituximab
CHEN Yong,GAO Yong-yan,LI Yan,LIANG Zhi-xiong.Literature analysis of 325 cases of adverse drug reactions of rituximab[J].Academic Journal of Guangdong College of Pharmacy,2010,26(2):179-181.
Authors:CHEN Yong  GAO Yong-yan  LI Yan  LIANG Zhi-xiong
Institution:1.The First Affiliated Hospital of Guangdong Pharmaceutical College,Guangzhou,Guangdong 510080;2.Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong 510120;3.Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China)
Abstract:Objective To investigate the adverse reactions of rituximab(Rituxan and MabThera) in retrospection to provide references for safe and rational drug use clinically.Methods A retrospective analysis was conducted on adverse reactions of rituximab during the period from 1999 to 2009 retrieved from CNKI database.Results The main ADRs were infusion reactions,and occurred mainly in the first intravenous drip.Conclusion The use of rituximab treatment should be closely monitored to ensure the safety of drug use.
Keywords:rituximab  Rituxan and MabThera  adverse drug reactions
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