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| 痛风灵胶囊镇痛作用及机制初探 | |
| 引用本文： | 唐春萍,江涛,龚梦鹃,杨超燕,肖逸翔,霍敏健. 痛风灵胶囊镇痛作用及机制初探[J]. 广东药学院学报, 2007, 23(3): 301-303 |
| 作者姓名： | 唐春萍 江涛 龚梦鹃 杨超燕 肖逸翔 霍敏健 |
| 作者单位： | 1. 广东药学院,中药药理教研室,广东,广州,510006 2. 广东药学院,实验动物中心,广东,广州,510006 3. 广东药学院,广东,广州,510006 |
| 摘 要： | 目的 观察痛风灵胶囊的镇痛效果,并探讨其作用机制.方法 采用热刺激引起小鼠疼痛反应法、冰醋酸刺激引起小鼠扭体反应法,以及甲醛法引起小鼠足疼痛反应,观察其镇痛作用,并采用甲醛疼痛模型观察其对炎症局部组织中前列腺素(PGE2)的影响.结果 痛风灵胶囊可以明显抑制醋酸导致的小鼠扭体反应,但对热刺激所致小鼠疼痛无明显镇痛作用,对甲醛所致小鼠第二相反应有明显抑制,降低炎症组织中的PGE2含量.结论 痛风灵胶囊对外周性疼痛有明显的镇痛作用,其机制与抑制炎症组织中PGE2生成有关. |
| 关 键 词： | 痛风灵胶囊 镇痛 前列腺素E2 |
| 文章编号： | 1006-8783（2007）03-0301-03 |
| 修稿时间： | 2007-05-122007-06-10 |
The study on the analgesic effects and mechanism of the Tongfengling capsules |
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| TANG Chun-ping, JIANG Tao, GONG Meng-juan, XIAO Yi-xiang, HUO Min-jian. The study on the analgesic effects and mechanism of the Tongfengling capsules[J]. Academic Journal of Guangdong College of Pharmacy, 2007, 23(3): 301-303 | |
| Authors: | TANG Chun-ping JIANG Tao GONG Meng-juan XIAO Yi-xiang HUO Min-jian |
| Affiliation: | Guangdong College of Pharmacy, Guangzhou , Guangdong 510006, China |
| Abstract: | Objective To investigate the analgesic effects and mechanism of Tongfengling(TFL) capsules. Methods Analgesic effects of TFL were observed with pain model mice induced with hot plate, writhing response induced with acetic acid and mouse formalin test. The content of PGE 2 was measured in mouse formalin test. Results TFL capsules could not elevate the pain threshold, but could inhibit writhing response and second phase of formalin test in mice, decreased the concentration of PGE2 in mouse formalin test. Conclusion TFL capsules has obvious analgesic effects, which was related to its inhibitory effects on peripheral inflammatory mediators PGE2. |
| Keywords: | Tongfengling capsules analgesic effect prostaglandin(PGE2) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |