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强化降脂治疗对高血压合并高脂血症患者颈动脉内膜中层厚度及颈动脉斑块的影响
引用本文:王亚蓉,韦建瑞,陈思伟.强化降脂治疗对高血压合并高脂血症患者颈动脉内膜中层厚度及颈动脉斑块的影响[J].广东药学院学报,2005,21(5):602-604.
作者姓名:王亚蓉  韦建瑞  陈思伟
作者单位:暨南大学医学院附属第四医院/广州市红十字会医院,心内科,广东,广州,510220
摘    要:目的 研究强化降脂治疗对高血压合并高脂血症患者的颈动脉内膜中层厚度及颈动脉斑块的影响. 方法 98例高血压合并高脂血症患者均给予常规降压治疗,并随机分为常规降脂治疗组(A组,n=48,予辛伐他汀20 mg/d)和强化降脂治疗组(B组,n=50,予辛伐他汀40 mg/d),治疗12周,比较两组治疗前后血压、血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)及颈动脉内膜中层厚度(CIMT)及颈动脉斑块的影响. 结果 B组治疗12周后收缩压(SBP)、舒张压(DBP)及血TC、TG、LDL及hs-CRP下降较A组更显著(P〈0.005), CIMT降低较A组更显著(P〈0.01),颈动脉斑块2、3级显著减少(P〈0.01).结论 高血压合并高脂血症患者强化降脂治疗可显著降低CIMT,并可明显消退颈动脉斑块.

关 键 词:高血压  高脂血症  颈动脉内膜中层厚度  颈动脉斑块
文章编号:1006-8783(2005)05-0602-03
收稿时间:05 24 2005 12:00AM
修稿时间:06 21 2005 12:00AM

The effect of intensive lipid-lowing therapy on carotid artery intima-media thickness and carotid atherosclerotic plaques in patients with hypertension complicated with hyperlipidemia
WANG Ya-rong,WEI Jian-rui,CHEN Si-wei.The effect of intensive lipid-lowing therapy on carotid artery intima-media thickness and carotid atherosclerotic plaques in patients with hypertension complicated with hyperlipidemia[J].Academic Journal of Guangdong College of Pharmacy,2005,21(5):602-604.
Authors:WANG Ya-rong  WEI Jian-rui  CHEN Si-wei
Institution:Dept. of Cardiology ,Fourth Affiliated Hospital of Medical College ,Jinan Unitersity/Gnangzhou Red-Cross Hospital, Gnangzhou 510220, China
Abstract:Objective To investigate the influence of intensive lipid-lowing therapy on carotid artery intima-media thickness(CIMT) and carotid atherosclerotic plaques in hypertension complicated with hyperlipidemia.Methods 98 patients with hypertension complicated with hyperlipidemia were randomly divided into two groups,routine therapy group(A group,n=48,20mg/d of simvastatin for 12 weeks) and intensive therapy group(B group,n=50,40mg/d simvastatin for 12 weeks).Blood pressure,serum TC,TG,HDL-C,LDL-C,hs-CRP, CIMT and carotid atherosclerotic plaques were determined in all patients before and after treatment.Results SBP,DBP,TC,TG,LDL-C,hs-CRP and CIMT were decreased more significantly in group B after treatment than those in group A(P<0.01).Carotid plaques 2-3 grade reduced significantly after treatment in B group(P<0.01).Conclusion Intensive lipid-lowering therapy can decreased CIMT and reduce carotid atherosclerotic plaques significantly.
Keywords:hypertension  hyperlipidemia  carotid artery intima-media thickness  carotid atherosclerotie plaques
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