| 微波辐射合成7-硝基-4（3H）-喹唑啉酮 |
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| 引用本文： | 柯洪琴,刘鹰翔,朱玉香.微波辐射合成7-硝基-4（3H）-喹唑啉酮[J].广东药学院学报,2009,25(3):285-287. |
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| 作者姓名： | 柯洪琴 刘鹰翔 朱玉香 |
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| 作者单位： | 1. 广东药学院,药科学院,广东,广州,510006
2. 广东药学院,药科学院,广东,广州,510006;广州中医药大学,中药学院,广东,广州,510006 |
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| 摘 要： | 目的用微波辐射法合成7-硝基-4（3H）-喹唑啉酮，研究微波功率、微波辐射时间和酸胺摩尔比等对反应收率的影响。方法以2-氨基4-硝基苯甲酸、甲酰胺为原料，采用微波辐射合成7-硝基-4（3H）-喹唑啉酮，并通过正交设计实验优化反应条件。结果最佳条件为：微波功率95W，辐射时间9min，酸胺摩尔比1：12，收率可高达96．8％，与常规加热法比较提高了约35％。结论微波辐射法对合成7-硝基-4（3H）-喹唑啉酮具有非常好的效果，与传统加热方法及文献方法相比，缩短了反应时间，提高了反应速率和收率。
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| 关 键 词： | 7-硝基-4(3H)-喹唑啉酮 微波辐射 正交设计 |
Synthesis of 7-nitro-4(3H)-quinazolinone under microwave irradiation |
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| KE Hong-qin,LIU Ying-xiang,ZHU Yu-xiang.Synthesis of 7-nitro-4(3H)-quinazolinone under microwave irradiation[J].Academic Journal of Guangdong College of Pharmacy,2009,25(3):285-287. |
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| Authors: | KE Hong-qin LIU Ying-xiang ZHU Yu-xiang |
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| Institution: | KE Hong-qin1,LIU Ying-xiang1,2,ZHU Yu-xiang1 (1.College of Pharmacy,Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China,2.Guangzhou University of Traditional Chinese Medicine,China) |
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| Abstract: | Objective To evaluate the effect of microwave irradiation on the synthesis of 7-nitro-4 （3H）- quinazolinone was investigated. Method 7-nitro-4 （3H）-quinazolinone was synthesized from 4- nitroanthranilic acid and formamide under microwave irradiation. The reaction conditions were optimized with orthogonal design. Result The optimum conditions were determined as follows： microwave power was 95 W, irradiation time was 9 min, and the molar ratio of 4-nitroanthranilic acid to formamide was 1 ： 12. Under above conditions, the yield of product might reach 96. 8%, increasing by 35% compared with conventional method. Conclusion 7-nitro-4 （3H）-quinazolinone was synthesized successfully under microwave irradiation. Compared with conventional method, the reaction time shortened and the reaction efficiency increased. |
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| Keywords: | 7-nitro-4(3H)-quinazolinone microwave irradiation orthogonal design |
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