清源化痰颗粒治疗慢性阻塞性肺疾病(COPD)发作期的临床研究

目的 进行清源化痰颗粒治疗慢性阻塞性肺疾病发作期痰热蕴肺，肺脾气虚证的临床疗效，观察探讨其作用机理。方法 治疗组采用清源化痰颗粒；对照组选用西药头孢拉定，氨茶碱，必嗽平，２组对照。结果 治疗组有总效率达９１．１８％，显控率为６４．７１％，明显优于对照组。实验结果见明显改善肺功能，降低肺动脉压，显著降低ＬＰＯ，ＥＴ－１，ＩＬ－８，ｓＩＬ－２Ｒ及ＮＯ含量，显著升高ＳＯＤ含量。

Clinical Study of Qingyuan Huatan Granule in Treating COPD

OBJECTIVE:To assess the clinical effects and mechanism of Qingyuan Huatan Granule (QHG) on the acute stage of chronic obstructive pulmonary disease (COPD) with the retention of phlegm-heat in the lung and Qi insufficiency of the lung and spleen. METHOD:QHG was given to the treatment group and western medicines (cefradine, aminophylline and bisolvon) to the control.RESULT:The total effective rate was 91.18% and the symptoms were significantly improved in 64.71% in the treatment group, higher than the control ( P <0.05). Pulmonary function was significantly improved. Pulmonary arterial pressure and the values of LPO, ET-1, IL-8, sIL-2R and NO were significantly lowered. The content of SOD was markedly raised. CONCLUSION:QHG has good clinical effects, possibly achieved through the following mechanisms: improving the immunity, suppressing lipid peroxidation, adjusting the balance of the oxidation-antioxidation system, relaxing smooth muscles, stopping the release of the inflammatory mediator and cytokine, and checking inflammation and damage.