| 表皮生长因子(EGF)影响舌苔形成的分子机制 |
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| 引用本文： | 周坤福,詹瑧,侯亮.表皮生长因子(EGF)影响舌苔形成的分子机制[J].南京中医药大学学报,2002,18(5):283-285. |
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| 作者姓名： | 周坤福 詹瑧 侯亮 |
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| 作者单位： | 南京中医药大学基础医学院,江苏,南京,210029 |
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| 基金项目： | 国家自然科学基金资助项目 (3 0 0 70 910 ) |
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| 摘 要： | 目的 通过皮下注射EGF，观察小鼠舌上皮细胞生长和EGF-R的表达，研究EGF影响舌苔形成的分子机制，方法 HE染色，EGF-RSABC免疫组化染色和图像分析数据处理系统（CMIAS-98A多功能图像分析仪）进行分析。结果 EGF促进小鼠舌上皮增厚，基底层细胞数增多，EGF-R表达增多。结论 EGF可以通过EGF-R机制影响舌苔形成。
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| 关 键 词： | 表皮生长因子 舌苔 免疫组化 图像分析 分子机制 |
| 文章编号： | 1000-5005(2002)05-0283-03 |
| 修稿时间： | 2002年3月17日 |
Molecular Mechanism of Epidermis Growth Factor (EGF) in Affecting Formation of Tongue Coating |
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| ZHOU Kun fu,ZHAN Zhen,HOU Liang.Molecular Mechanism of Epidermis Growth Factor (EGF) in Affecting Formation of Tongue Coating[J].Journal of Nanjing University of Traditional Chinese Medicine(Natural Science),2002,18(5):283-285. |
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| Authors: | ZHOU Kun fu ZHAN Zhen HOU Liang |
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| Abstract: | OBJECTIVE EGF was injected to observe the growth of tongue epithelium of mice and EGF-R expression, so as to investigate into the molecular mechanism of EGF in affecting the formation of tongue coating. METHOD HE pigmentation, EGF-R SABC immunology and histochemistry pigmentation and graph analysis and data processing system (CMIAS-98A multifunctional graph analyzer) were used in the analysis.RESULT EGF could promote the thickening of the mice tongue epithelium and increase the number of basal cells and EGF-R expression.CONCLUSION EGF can affect the formation of tongue coating through EGF-R. |
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| Keywords: | epidermis growth factor tongue coating immunology and histochemistry graph analysis molecular mechanism |
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