| 氯诺昔康滴丸的制备工艺及质量标准研究 |
| |
| 引用本文： | 魏凯,李欣.氯诺昔康滴丸的制备工艺及质量标准研究[J].中国伤残医学,2010,18(3). |
| |
| 作者姓名： | 魏凯 李欣 |
| |
| 作者单位： | 1. 黑龙江天宏药业有限公司,黑龙江,哈尔滨,150025
2. 哈尔滨市食品药品检验检测中心 |
| |
| 摘 要： | 目的:确立氯诺昔康滴丸的最佳成型工艺和研究建立氯诺昔康滴丸的质量标准。方法:采用正交试验设计法,对药物与基质的用量,药料温度和冷却液上部温度进行了优选。采用高效液相色谱法对滴丸中氯诺昔康进行含量测定。结果:根据实验所确定的工艺,制备3批样品,符合中国药典关于滴丸的规定。氯诺昔康可以用HPLC法测定含量,氯诺昔康的线性范围在4.01μg/ml～16.03μg/ml(r=0.9999),平均回收率为99.9%,RSD%<2.0%(n=6)。结论:优选的制备工艺简便可行,所建立的质量标准能检测和确定制剂中氯诺昔康的含量,且方法简便、灵敏、快速、准确。
|
| 关 键 词： | 氯诺昔康滴丸 制备工艺 氯诺昔康 高效液相色谱法 |
The Study on Preparation Procedure and Quality Standard of Lomoxicam Dropping Pills |
| |
| WEI Kai,LI Xin.The Study on Preparation Procedure and Quality Standard of Lomoxicam Dropping Pills[J].Chinese JOurnal of Trauma and Disability Medicine,2010,18(3). |
| |
| Authors: | WEI Kai LI Xin |
| |
| Institution: | WEI Kai,LI Xin(Heilongjiang Timehome Pharmaceutical Co.Ltd.,Harbin 150025) |
| |
| Abstract: | Objective:To establish the optimized preparation procedure and study on quality standards of Lomoxicam Dropping Pills.Methods:Orthogonal experimental design method,the matrix of the drug and dosage,medicine feed the upper part of coolant temperature and the temperature was preferred.The use of high-performance liquid chromatography pills in Lomoxicam for determination.Results:According to the laboratory to determine the process to prepare the sample batch 3,in line with the Chinese Pharmacopoeia on the Pill... |
| |
| Keywords: | Lomoxicam Dropping Pills Preparation procedure Lomoxicam HPLC |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
