通心络对急性一氧化碳中毒患者血管内皮功能的保护作用

目的观察急性一氧化碳中毒(ACOP)患者血中一氧化氮(NO)和内皮素(ET)含量的变化,探讨通心络对其血管内皮功能的保护作用。方法选择ACOP患者90例,随机分为对照组和治疗组各45例,对照组予常规治疗,治疗组加用通心络胶囊,观察2组的治疗效果,并随访迟发性脑病发生率,分别测定2组患者治疗前后NO和ET含量的变化,并与20名健康体检者(健康组)进行对比分析。结果观察组总有效率(95.6%)明显优于对照组(82.2%),差异有统计学意义(P<0.05)。ACOP患者NO含量较健康组明显降低(P<0.01),而ET含量显著升高(P<0.01);2组治疗后NO、ET含量均较治疗前有显著变化(P<0.05,P<0.01);且与对照组比较,通心络治疗后NO含量明显升高(P<0.05),ET含量显著降低(P<0.05)。观察组和对照组分别发生迟发性脑病8例(17.8%)和2例(4.4%),差异有统计学意义(P<0.05)。结论通心络通过促进NO的分泌,抑制ET的产生,发挥对ACOP患者受损血管内皮功能的保护作用。

The protective action of Tongxinluo on vascular endothelial function in acute carbon monoxide poisoning patients

Objective To observe the changes of nitric oxide(NO)and endothelin(ET)in acute carbon monoxide poisoning (ACOP)patients and investigate the protective action of Tongxinluo capsule on the vascular endothelial function.Methods The total of 90 ACOP patients were randomly divided into the treatment group and control group.By nitrate reduction and radio immunity method,two groups of patients respectively measured changes of NO and ET before and after treatment,and compared with 20 of healthy volunteers(normal group).Observed the treatment effect and the incidence of the delayed encephalopathy in the two groups.Results Compared with the healthy group,the content of NO was lower obviously(P<0.01)in treatment group,ET significantly increased in ACOP patients(P<0.01);NO and ET had significant differences after treatment both in control group and in treatment group(P<0.05,P<0.01).Moreover,compared with the control group,NO increased and ET reduced in Tongxinluo group(P<0.05).Conclusion Tongxinluo can protect the damaged vascular endothelial function of the ACOP patients by promoting NO secretion,inhibiting the generation of ET.