苦碟子辅助神经营养因子对脑梗死后神经功能缺损患者脑血灌注量、血管内皮及神经功能的影响

目的观察苦碟子辅助神经营养因子对脑梗死后神经功能缺损患者脑血灌注量、氧化应激反应及神经功能指标水平的影响。方法选取2014年1月-2018年12月湖北省天门市第一人民医院神经内科收治的急性脑梗死患者141例作为研究对象,采用随机数字表法分成2组。2组患者均予脑梗死常规治疗,对照组使用单唾液酸四己糖神经节苷脂钠治疗,观察组在对照组基础上加用苦碟子治疗,治疗2周后比较2组患者治疗有效率,治疗前后脑血灌注量指标脑血流量(CBF)、脑血平均通过时间(MTT)],血管内皮功能指标血浆内皮素(ET)、一氧化氮(NO)],神经功能指标血清神经元特异性烯醇化酶(NSE)、S100B蛋白],美国国立卫生研究院卒中量表(NIHSS)评分等。结果治疗2周后,观察组治疗总有效率为97.18%,高于对照组的78.57%(χ^2/P=11.515/0.001);观察组CBF、NO水平高于对照组(t/P=25.949/0.000、8.368/0.000),而MTT、血浆ET、血清NSE、SE、S100B水平、NIHSS评分低于对照组(t/P=28.185/0.000、8.987/0.000、6.223/0.000、18.058/0.000、7.551/0.000)。结论苦碟子辅助神经营养因子能改善脑梗死后神经功能缺损患者脑血灌注量、氧化应激反应及神经功能指标,提高临床治疗效果。

Effects of Kudiezi assisting neurotrophic factors on cerebral blood perfusion volume,vascular endothelial function and serum neurological function in patients with a neurological deficit after CI

Objective To study the effects of Kudiezi assisting neurotrophic factors on cerebral blood perfusion volume,oxidative stress response and serum neurological function indexes levels in patients with a neurological deficit after cerebral infarction.Methods A total of 141 patients with acute cerebral infarction who were admitted to Tianmen First People Hospital,Hubei,from January 2014 to December 2018 was enrolled as study objects.They were randomly divided into two groups.The control group was treated with monosialotetrahexosyl ganglioside sodium.On this basis,the observation group was additionally treated with Kudiezi.The response rate of treatment,cerebral blood perfusion volume indexes cerebral blood flow(CBF),mean transition time(MTT)],vascular endothelial function indexes plasma endothelin(ET),plasma nitric oxide(NO)],serum neurological function indexes neuron specific enolase(NSE),S100 B protein],score of National Institutes of Health Stroke Scale(NIHSS) before and after treatment were analyzed and compared between the two groups.Results After treatment,the total response rate of treatment in the observation group was higher than that in control group(97.18% vs.78.51%)(χ^2/P=11.515/0.001).After 2 weeks of treatment,levels of CBF and NO in observation group were higher than those in control group(t/P=25.949/0.000,t/P=8.368/0.000),while levels of MTT,plasma ET,serum NSE,and S100 B,and NIHSS scores were lower than those in control group(t/P=28.185/0.000,t/P=8.987/0.000,t/P=6.223/0.000,t/P=18.058/0.000,t/P=7.551/0.000).Conclusion Kudiezi assisting neurotrophic factors can improve cerebral blood perfusion volume,oxidative stress response and serum neurological function indexes in patients with a neurological deficit after cerebral infarction,and improve clinical curative effect.