| 替罗非班对ST段抬高型AMI患者PCI后心肌灌注及心血管事件的影响 |
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| 引用本文： | 晋辉.替罗非班对ST段抬高型AMI患者PCI后心肌灌注及心血管事件的影响[J].疑难病杂志,2011,10(1):7-9. |
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| 作者姓名： | 晋辉 |
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| 作者单位： | 河南省焦作市人民医院心血管内科一区,454002 |
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| 摘 要： | 目的观察替罗非班对ST段抬高型心肌梗死(STEMI)患者冠状动脉介入术(PCI)后心肌灌注及心血管事件的影响。方法首次因STEMI行急诊PCI治疗的102例患者,随机分为对照组50例和替罗非班组52例。对照组予常规PCI;替罗非班组于PCI中给予盐酸替罗非班,观察2组PCI术后15 min校正的TIMI帧数计数(CTFC)并进行冠状动脉血流速度测定;记录住院期间主要心血管事件(MACE)发生率。结果 2组患者术前基本资料比较,差异无统计学意义(P均>0.05);替罗非班组CTFC和冠状动脉血流速度较对照组明显改善(P<0.05);治疗24 h后血清cTnT峰值水平明显低于对照组(P<0.05);术后10 d左室射血分数(LVEF)显著高于对照组(P<0.05);30d内的MACE发生率显著低于对照组(P<0.05);2组出血并发症发生率差异无统计学意义(P>0.05)。结论在STEMI行PCI治疗时应用替罗非班,可明显改善心肌再灌注,减轻心肌损害,减少PCI术后患者MACE发生率,并且不增加出血并发症发生率。
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| 关 键 词： | 替罗非班 心肌梗死 ST段抬高型 经皮冠状动脉介入术 心肌灌注 心血管事件 |
Effect of tirofiban on myocardial reperfusion and major cardiovascular events after percutaneous coronary intervention in ST segment elevation myocardial infarction |
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| JIN Hui.Effect of tirofiban on myocardial reperfusion and major cardiovascular events after percutaneous coronary intervention in ST segment elevation myocardial infarction[J].Journal of Difficult and Complicated Cases,2011,10(1):7-9. |
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| Authors: | JIN Hui |
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| Institution: | JIN Hui.Department of Cardiology,the People's Hospital of Jiaozuo City,Henan Province,Jiaozuo 454002,China |
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| Abstract: | Objective To observe the effect of tirofiban on reperfusion and major adverse cardiovascular events (MACE) after percutaneous coronary intervention(PCI) in patients with ST segment elevation myocardial infarction(STEMI). Methods Totally 102 patients with STEMI treated with PCI,were designed into two groups randomly:control group (50 cases) and tirofiban group(52 cases).The tirofiban group received tirofiban during the course of PCI,while conventio nal treatment was applied in control group.Corrected TIMI fr... |
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| Keywords: | Tirofiban Myocardial infarction ST segment elevation Percutancous coronary intervention Myocardial perfusion Major adverse cardiovascular events |
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