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帕金森病患者肌张力的客观定量分析
引用本文:杨明会,李敏,李绍旦,刘毅.帕金森病患者肌张力的客观定量分析[J].疑难病杂志,2010,9(11):811-813.
作者姓名:杨明会  李敏  李绍旦  刘毅
作者单位:解放军总医院中医研究所,北京,100853
基金项目:"十一五"国家科技支撑计划重大项目 
摘    要:目的研究快速肌张力检测仪在对帕金森病(PD)患者进行肌张力测定时的质控标准。方法将60例PD患者随机分成治疗组和对照组各30例,2组均以西药美多巴为基础治疗,治疗组服用补肾活血颗粒,对照组服用安慰剂。2组均观察3个月。排除受试者肌肉状态、脂肪厚度等方面的影响,在肌肉测试对象的选择、快速肌张力检测仪的校准、预设程序的力量、操作者质控、受试者配合和重复性等方面制定操作标准。采用快速肌张力检测仪测量每例患者肱二头肌和股四头肌在治疗前、治疗后3个月肌肉弹性变化,用压力—位移曲线下面积来描述肌肉弹性硬度和肌肉顺应性变化。结果 (1)肱二头肌肌张力比较:左侧静息状态下治疗前后差异有统计学意义(P〈0.01),而最大自主收缩状态下治疗前后差异无统计学意义(P〉0.05).右侧静息状态和最大自主收缩状态下差异均无统计学意义(P〉0.05)。(2)股四头肌肌张力比较:左侧静息状态下治疗前后差异有统计学意义(P〈0.01),而最大自主收缩状态下治疗前后差异无统计学意义(P〉0.05),右侧静息状态和最大自主收缩状态下差异均无统计学意义(P〉0.05)。结论通过对快速肌张力检测仪操作过程进行标准化,可以较为精确地测量PD患者肌肉状态的变化。

关 键 词:帕金森病  肌张力  快速肌张力检测仪

Objective analysis of muscles tension in patients suffered Parkinson' s disease
Institution:YANG Ming-hui.LI Min,LI Shao-Dan,et al.Department of Traditional Chinese Medicine,General Hospital of PLA,Beijing 100853,China
Abstract:Objective To investigate the quality control standard for the operating of Myotonometer,which was used to measure muscular tension in patients suffered Parkinson's disease.Methods 60 patients were enrolled and divided into two groups randomly.Control group were treated with placebo and treatment group with Bushenhuoxue granules,both groups based on madopar treatment.Follow up lasted for 3 months;Myotonometer was employed to measure muscular tension changes of the biceps brachii and quadriceps femoris at baseline time and at 3 months.Area under curve(AUC) was used to describe the changes of muscular tension.Results(1) Biceps brachii muscular tension;there was statistic difference between pre and post treatment in the left side under rest stage(P0.01) while no difference at maximum voluntary contraction(MVC) stage(P0.05);no difference was found on right side under rest stage or MCV stage(P0.05).(2) Quadriceps femoris muscular tension;there was statistic difference between pre and post treatment in the left side under rest stage(P0.01 ),while no difference at maximum voluntary contraction(MVC) stage(P0.05);no difference was found on right side under rest stage or MCV stage(P0.05).Conclusion Based on quality control of the operating step of Myotonometer,muscular tension measurement in patients suffered from Parkinson's disease can be more accurate.
Keywords:Parkinson's Disease  Muscular tension  Myotonometer
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