高血压病合并急性脑梗死患者血清视黄醇结合蛋白4与心率变异性的关系

目的探讨高血压病合并急性脑梗死患者血清视黄醇结合蛋白4(RBP4)与心率变异性(HRV)之间的关系。方法选择78例高血压病合并急性脑梗死患者为观察组,以50例单纯高血压病为对照组。采用酶联免疫吸附法测定受试者血清RBP4水平,用动态心电监护仪监测HRV时域参数,包括24h所有窦性心搏R-R间期的标准差(SDNN)、24h每5分钟窦性心搏R—R问期平均值的标准差(SDANN)、24h每5分钟所有窦性心搏R-R间期标准差的均值(SDNNindex)、相邻窦性心搏R-R间期差值的均方根(rMSSD)、24h相邻窦性心搏R-R间期差值超过50ms的百分比(PNN50)。结果对照组与观察组患者血清RBP4水平分别为(15.5±5.4/24.2±7.6)mg/L,差异具有统计学意义(P<0.01)。对照组与观察组的HRV时域参数分别为SDNN(112.3±21.9/79.7±19.1)ms、SDANN(36.1±9.3/25.8±7.2)ms、SDNNindex(96.7±26.8/81.3±25.0)ms、rMSSD(23.2 4±7.9/19.4±5.7)ms、PNN50(8.9±4.1/5.7±3.2)%,观察组均低于对照组,差异具有统计学意义(P<0.05)。血清RBP4与SDNN、SDANN、SDNNindex、rMSSD、PNN50均呈显著负相关(r=-0.483、r=-0.452、r=-0.414、r=-0.293、r=-0.286,P<0.01或P<0.05)。结论血清视黄醇结合蛋白4与HRV各参数呈显著负相关,可能参与高血压病合并急性脑梗死患者自主神经功能调节失衡的形成。

Relationship between serum retinol binding protein 4 and the heart rate variability in hypertension patients with acute cerebral infarction

Objective To investigate the relationship between serum retinol binding protein 4(RBP4) and heart rate variability(HRV) in hypertension patients with acute cerebral infarction.Methods 78 cases of hypertension patients with acute cerebral infarction were enrolled in the observation group,50 cases of simple hypertension patients were enrolled in the control group.Enzyme linked immunosorbent assay of serum RBP4 levels of the subjects were measured,ambulatory blood pressure were used to monitor heart rale variability time domain parameters,included SDNN,SDANN,SDNN index,rMSSD and PNN50.Results The serum retinol binding protein 4 levels in control group and observation group were(15.5±5.4) mg/ L and(24.2±7.6)mg/L respectively,the difference between them was statistically significant(P<0.01).The time domain HRV parameters in control group and observation group were as follows,SDNN(112.3±21.9 vs.79.7±19.1) ms,SDANN (36.1±9.3 vs.25.8±7.2)ms,SDNN index(96.7±26.8 vs.81.3±25.0)ms,rMSSD(23.2±7.9 vs.19.4±5.7)ms, PNN50(8.9±4.1 vs.5.7±3.2)%.these data in the observation group were lwoer than in the control group,the differences were statistically significant(P<0.05).Pearson linear correlation analysis showed that serum RBP4 and SDNN(r = -0. 483,P<0.01),SDANN(r=-0.452,P<0.01),SDNN index(r=-0.414,P<0.01),rMSSD(r=-0.293,P<0.05),PNN50(r=-0.286,P<0.05) were negative correlated.Conclusion The serum retinol binding protein 4 was negative correlated with heart rate variability parameters.Serum retinol binding protein 4 might be part of autonomic imbalance in hypertension patients with acute cerebral infarction.