| 急性肾功能衰竭家兔机体抗氧化能力的变化 |
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| 引用本文： | 赵自刚,张秀昌,牛春雨,刘军超,何景力,张静.急性肾功能衰竭家兔机体抗氧化能力的变化[J].疑难病杂志,2003,2(1):5-6. |
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| 作者姓名： | 赵自刚 张秀昌 牛春雨 刘军超 何景力 张静 |
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| 作者单位： | 1. 075000,张家口医学院病理生理教研室
2. 075000,张家口医学院大学生科协 |
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| 基金项目： | 张家口市科委资助项目 (NO :0 11114 ) |
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| 摘 要： | 目的 探讨急性肾功能衰竭 (ARF)家兔机体抗氧化能力的变化及其意义。方法 30只家兔随机分为 2组 ,对照组和ARF模型组各 15只。以 1%HgCl2 复制家兔ARF模型 ,分别应用改良TBA微量法、黄嘌呤氧化酶法测定血清及肾组织匀浆的丙二醛 (MDA)水平、超氧化物歧化酶 (SOD)活性的变化。结果 ARF组血清及肾组织匀浆的MDA水平高于对照组 (P <0 .0 1) ,SOD活性显著低于对照组(P <0 .0 1)。结论 急性肾功能衰竭时机体抗氧化能力明显降低
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| 关 键 词： | 肾功能衰竭 急性 超氧化物歧化酶 疾病模型 动物 |
| 文章编号： | 1671-6450(2003)01-0005-02 |
| 修稿时间： | 2002年8月26日 |
Changes of antioxidation ability in rabbit with acute renal failure |
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| ZHAO Zigang ,ZHANG Xiuchang,NIU Chunyu,et al..Changes of antioxidation ability in rabbit with acute renal failure[J].Journal of Difficult and Complicated Cases,2003,2(1):5-6. |
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| Authors: | ZHAO Zigang ZHANG Xiuchang NIU Chunyu |
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| Institution: | ZHAO Zigang *,ZHANG Xiuchang,NIU Chunyu,et al. *Department of Pathophysiology,Zhangjiakou Medical College,Zhangjiakou 075000,China |
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| Abstract: | Objective To inquire into the changes and meanings of antioxidation ability in rabbits with acute renal failure(ARF).Methods 30 rabbits were randomly divided into two groups:the control group(n=15),the ARF group(n=15).The ARF model of rabbit was copied by 1% HgCl 2,the malondialdehyde(MDA),superoside dismutase(SOD)content in serum and renal homogenate were determined by modificatory TBA microdetermination,xanthinoxidanse method.Results It showed that MDA content in serum and renal homogenate of ARF group was significantly increased than that of control group (P<0.01),and the SOD content was signifcantly lower than that of control group(P<0.01).Conclusion The results suggested that the antioxidation ability decreased obviously in acute renal failure. |
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| Keywords: | Acute renal failure Superoside dismutase Disease model animal |
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