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稳心颗粒联合氟伐他汀对高血压病并发心房纤颤患者心房肌重构的干预作用
引用本文:董艳,邢兰访,李保民,佟翠娟.稳心颗粒联合氟伐他汀对高血压病并发心房纤颤患者心房肌重构的干预作用[J].疑难病杂志,2010,9(8):566-568.
作者姓名:董艳  邢兰访  李保民  佟翠娟
作者单位:河北省唐山市人民医院急诊科,063000
摘    要:目的探讨稳心颗粒联合氟伐他汀对高血压病并发阵发性房颤患者心房肌重构的干预作用。方法将86例高血压病并发阵发性心房颤动患者随机分为治疗组与对照组,2组均接受常规降压治疗,治疗组在此基础上给予稳心颗粒(9 g,每天3次)联合氟伐他汀(40 mg/d)口服,治疗随访12个月。治疗前及治疗后每3个月分别记录2组的心电图、24h动态心电图、心脏彩色超声,测量P波最大时限(Pmax)、P波离散度(Pd)、左房直径(LAD)、左房最大容积(LAVmax)和A峰峰值流速(V_A)、左房射血力(LAEF),并观察房颤复发情况。结果治疗组房颤复发率明显少于对照组(23.3%vs 48.8%,P〈0.05);治疗12个月后,窦性心律时,对照组除LAEF较治疗前显著改善外(P〈0.05),其余各指标均无显著改善(P〉0.05);治疗组除LAD较治疗前无显著改善外(P〉0.05),其余各指标均显著改善(P〈0.05),且与对照组治疗后比较,差异亦有统计学意义(P〈0.05)。结论稳心颗粒联合氟伐他汀可改善高血压病并发阵发性房颤患者的心房肌重构。

关 键 词:稳心颗粒  氟伐他汀  高血压病  心房颤动  心房肌重构

Effect of Wenxin particle combine with fluvastatin on atrial remodelling in essential hypertension patients with atrial fibrillation
Institution:DONG Yan,XING Lan-fang,LI Bao-min,et al.Department of Emergency,Tangshan People's Hospital,Hebei Province,Tangshan 063000,China
Abstract:Objective To investigate the therapeutic effect of Wenxin particle combine with fluvastatin on atrial remodeling in essential hypertension patients with atrial fibrillation.Methods Eighty-six essential hypertension patients with atrial fibrillation were randomly divided into control group and treatment group.The patients in both two groups received conventional antihypertensive therapy,in addition,patients in treatment group received Wenxin particle (9 g/tid) and fluvastatin(40 mg/d),and follow up 12 months.Echocardiography examination including left atrial diameter(LAD) and maximal volume(LAVmax),peak A velocity(V_A),left atrial ejection force(LAEF) were monitored,12 lead electrocardiography P wave maximal duration(Pmax),P wave dispersion(Pd) were measured before and after treatment and per three months in follow up period.Results The recurrency of atrial fibrillation reduced obviously in treatment group than control group(23.3%vs 48.8%,P0.05).After 12 months,the observation indexes did not obviously improved in control group,except for LAEF(P0.05),while all indexes improved obviously in treatment group than control group(P0.05),except for LAD(P0.05).Conclusion It demonstrated that Wenxin particle combined with fluvastatin could improve atrial remodeling in essential hypertension patients with atrial fibrillation.
Keywords:Wenxin particle  Fluvastatin  Essential hypertension  Atrial fibrillation  Atrial remodeling
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