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硫酸吗啡控释片口服与直肠给药控制癌性疼痛的临床观察
引用本文:曹科,张印.硫酸吗啡控释片口服与直肠给药控制癌性疼痛的临床观察[J].疑难病杂志,2009,8(4):214-215.
作者姓名:曹科  张印
作者单位:解放军总医院中医科,北京,100853
摘    要:目的采用交叉设计法观察硫酸吗啡控释片口服给药和直肠给药对中、重度癌性疼痛的止痛效果及不良反应。方法将78例中、重度癌性疼痛的患者随机分为A组(39例)、B组(39例)。A组硫酸吗啡控释片先口服给药后再直肠给药,B组先直肠给药后再口服给药,各用5d,重度疼痛者剂量为30mg/12h,中度疼痛者剂量为10mg/12h。结果口服给药总有效率为88.5%,直肠给药总有效率为91.0%,组间差异无统计学意义(P>0.05)。口服给药与直肠给药的不良反应临床表现相同,未见呼吸抑制、成瘾性等严重的不良反应。口服给药不良反应(恶心、呕吐,腹胀、便秘,排尿困难,嗜睡等)总发生率为38.5%,直肠给药总发生率为25.6%,差异有统计学意义(P<0.05)。结论硫酸吗啡控释片直肠给药的止痛疗效与口服给药相同,不良反应少于口服给药。

关 键 词:疼痛  癌性  硫酸吗啡控释片  口服给药  直肠给药

Releasing the cancer pain with morphine sulphate controlled-release tablets through orally and rectally administrations
CAO Ke,ZHANG Yin.Releasing the cancer pain with morphine sulphate controlled-release tablets through orally and rectally administrations[J].Journal of Difficult and Complicated Cases,2009,8(4):214-215.
Authors:CAO Ke  ZHANG Yin
Institution:. Department of Traditional Chinese Medicine, the PLA General Hospital, Beijing 100853,China
Abstract:Objective To observe the analgesic effects and adverse reactions which using crossover design controlled-release morphine sultate tablets tirough orally and rectally administration on moderate or severe cancer pain. Methods Seventy-eight cases of moderate and severe cancer pain were randomly divided into A (39 cases) and B (39 cases)group. In the A group, controlled-release morphine sulfate lablets were adminstrated with orally firstly, and then rectalLy administration for 5 days, respectively. While in B group, firstly administrated through rectally, and then oralLy for 5 day's, respectively. For the cases with severe cancer pain, the dosage was 30 mg/12 h, and for the cases with moderate cancer pain, the dosage was 10 mg/12 h. Results The totally effective rate of orally administration was 88.5%, and rectally administration was 91.0%. There was no statistical difference between two groups ( P 〉 0.05). In both groups, there were same side effects, mainly nausea, vomiting, abdominal distension, constipation, drowsiness, difficulty urinating; no serious adverse reactions were presented, such as respiratory depression, addiction and so on. The incidence of adverse reactions in orally administration was 38.5%, in rectally administration was 25.6%, and there was statistically significant differences in two means ( P 〈0. 05). Conclusion It showed that morphine sulfate controlled-release tablets through rectally had the same efficacy, compared with orally administration, furthermore, the adverse reactions less than latter.
Keywords:Cancer pain  Morphine sulfate controlled-release tablets  Orally administration  Rectally administration
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