通心络对颈动脉粥样硬化患者脑血流动力学的影响

目的　研究颈动脉粥样硬化伴脑供血不足患者 ,用通心络治疗前后血流动力学的变化。方法　给予 53例有颈动脉粥样硬化的脑供血不足的患者服用通心络胶囊 4粒 ,每日 3次 ,疗程为 4周。治疗前后采用经颅彩色多普勒 (transcranialdoppler,TCD)检测颅内各血管的血流变化 ,并与 30例老年健康体检者进行对照。结果　脑供血不足组各血管平均血流速度 (Vm)与健康对照组比较明显降低 (P <0 .0 5或 P <0 .0 1 ) ,且多数血管搏动指数 (PI)升高 (P <0 .0 5) ;治疗后脑供血不足组各血管的Vm较治疗前有显著性增高 (P <0 .0 5) ,且PI较治疗前有显著性降低 (P <0 .0 5)。结论　通心络可改善颈动脉粥样硬化患者的脑供血 ,是治疗和预防脑供血不足的有效药物

Effect of Tongxinluo on the cerebral hemodynamics in paitents with carotid atherosclerosis

Objective To investigate the effect of Tongxinluo on the cerebral hemodynamics in carotid atherosclerosis patients complicated by cerebral ischemia.Methods 53 patients with carotid atherosclerosis complicated by cerebral ischemia were treated with Tongxinluo capsule,four pills once,three times a day,for a treatment course of four weeks.The hemodynamic changes of patients were examined by TCD before and after treamtment,which were compared with those of 30 aged healthy subjects.Results The average blood flow velocity (Vm) in patients with cerebral ischemia decreased significantly,compared with that of healthy subjects (P<0.05 or P<0.01),while the pulse index(PI) of patients increased obviously(P<0.05);after treatment the Vm of patients increased and PI decreased significantly(P<0.05).Conclusion Tongxinluo capsule can improve the cerebral blood supply of patients,which is effective in treating patients with carotid atherosclerosis complicated by cerebral ischemia.