补肾益气法、活血祛瘀法治疗血管性痴呆的实验研究

目的　研究补肾益气法、活血祛瘀法对血管性痴呆大鼠的治疗作用 ,寻找最佳治疗方案。方法　采用双侧颈总动脉永久性结扎造成血管性痴呆大鼠模型 ,治疗后观察药物对血管性痴呆大鼠学习记忆能力的改善 ,海马CAI区锥体细胞的保护作用。结果　 ( 1)统计学结果表明 ,补肾益气法、活血祛瘀法可以改善血管性痴呆大鼠学习记忆能力 ,与模型组相比较有显著性差异 (P <0 .0 5～ 0 .0 1)。( 2 )组织形态学研究表明 :补肾益气法、活血祛瘀法有减轻缺血对海马CAI区锥体细胞损伤的作用。结论　中药补肾益气法、活血祛瘀法为治疗血管性痴呆大鼠的有效方法 ,其中活血祛瘀法作用更显著。

Experimental study on TKQ and PBC in the treatment of vascular dementia in rats

Objective To investigate the therapeutic effects of tonifying kidney Qi (TKQ ) and promoting blood circulation to remove blood stasis (PBC) on vascular dementia (VD) in rats.Methods The VD model of rats was made by permanent occlusion of bilateral common carotid arteries. After the therapy of TKQ and PBC, the learning and memory ability and the neuropathological changes of pyramidal neuron in hippocampus CA1 region in the brain of VD rats were observed.Results (1)The therapy of TKQ and PBC could significantly improve the learning and memory ability of VD rats, as compared with the control rats (P<0.05 or P<0.01).(2) The therapy of TKQ and PBC had the effect of relieving the damage caused by ischemia in pyramidal neuron of hippocampus CA1 region in the brain of VD rats.Conclusion The therapy of TKQ and PBC is effective in treating VD in rats and the PBC therapy may be more available.