| Effects of Ropivacaine and Bupivacaine on Rabbit Myocardial Energetic Metabolism and Mitochondria Oxidation |
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| 作者姓名： | 张诗海 姚尚龙 李晴 |
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| 作者单位： | Department of Anesthesiology，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Department of Anesthesiology，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Department of Anesthesiology，Xiehe Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022 |
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| 摘 要： | Summary:To compare the cardiotoxicity induced by ropivacaine and bupivacaine and to investigatethe mechanism of cardiotoxicity,24 mature New Zealand rabbits were divided randomly into controlgroup(group C),ropivacaine group(group R)and bupivacaine group(group B).Hearts were drawnout rapidly from the anesthetized animals and cardiac perfusion was performed immediately.Ropiva-caine 500 ng/ml(group R)or bupivacaine 500 ng/ml(group B)was added to the perfusion solution.Ventricular myocardial ATP,ADP and AMP were measured with high performance liquid chro-matogram.The ability of myocardial mitochondria oxidation to pyruvate or palmitoylcarnitine wasdetected with Clark electrode.Our results showed that myocardial ATP and ADP decreased signifi-cantly(P<0.05)in group R and most significantly(P<0.01)in group B as compared with groupC.Myocardial ATP and ADP decreased most significantly(P<0.01)in group B as compared withgroup R.The changes of myocardial AMP revealed significant difference among three groups.Thecha
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| 收稿时间： | 24 June 2002 |
Effects of ropivacaine and bupivacaine on rabbit myocardial energetic metabolism and mitochondria oxidation |
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| Zhang?Shihai,Yao?Shanglong,Li?Qing.Effects of Ropivacaine and Bupivacaine on Rabbit Myocardial Energetic Metabolism and Mitochondria Oxidation[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(2):178-179. |
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| Authors: | Zhang Shihai Yao Shanglong Li Qing |
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| Institution: | Department of Anesthesiology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 |
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| Abstract: | To compare the cardiotoxicity induced by ropivacaine and bupivacaine and to investigate the mechanism of cardiotoxicity, 24 mature New Zealand rabbits were divided randomly into control group (group C), ropivacaine group (group R) and bupivacaine group (group B). Hearts were drawn out rapidly from the anesthetized animals and cardiac perfu-sion was performed immediately. Ropivacaine 500 ng/ml (group R) or bupivacaine 500 ng/ml (group B) was added to the perfusion solution. Ventricular myocardial ATP, ADP and AMP were measured with high performance liquid chro-matogram. The ability of myocardial mitochondria oxidation to pyruvate or palmitoylcarnitine was detected with Clark electrode. Our results showed that myocardial ATP and ADP decreased significantly (P<0. 05) in group R and most significantly (P<0. 01) in group B as compared with group C. Myocardial ATP and ADP decreased most significantly (P<0. 01) in group B as compared with group R. The changes of myocardial AMP revealed significant difference among three groups. The changes of pyruvate oxidation exibited no significant difference among the three groups. Palmitoylcarnitine oxidation decreased markedly (P<0. 05) in group R and most significantly (P<0. 01) in group B as compared with group C. The present study indicated that the inhibition of lipid substrate oxidation may be responsible for the cardiotoxicity induced by bupivacaine and ropivacaine. The cardiotoxicity induced by ropivacaine is far more less than bupivacaine. |
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| Keywords: | bupivacaine ropivacaine toxicity mitochondria |
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