| Determination of Carboplatin Dose by Area Under the Curve in Combination Chemotherapy for Senile Non-small Cell Lung Cancer |
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| 引用本文： | 殷铁军,刘菁菁,胡长耀,刘梦涛. Determination of Carboplatin Dose by Area Under the Curve in Combination Chemotherapy for Senile Non-small Cell Lung Cancer[J]. 华中科技大学学报(医学英德文版), 2007, 27(6): 710-712. DOI: 10.1007/s11596-007-0624-x |
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| 作者姓名： | 殷铁军 刘菁菁 胡长耀 刘梦涛 |
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| 作者单位： | Department of Comprehensive Medicine Huazhong University of Science and Technology，Department of Comprehensive Medicine Huazhong University of Science and Technology，Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Comprehensive Medicine Huazhong University of Science and Technology，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China |
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| 基金项目： | This project was supported by a grant from a key research program of the Education Bureau of Hubei Province （D2006-02-002）. |
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| 摘 要： | To preliminarily determine the appropriate dosage of carboplatin (CBP) at AUC of 5 mg·Ml-1·min-1 in the combination chemotherapy for Chinese senile patients with non-small cell lung cancer (NSCLC). Thirty-five Chinese senile patients with NSCLC in advanced stage (Ⅲ/Ⅳ) were given 96 cycles of combination chemotherapy. Chemotherapy schedules included Taxol CBP, Gemzar CBP and NVB CBP. The dose of CBP was at 5 mg·mL-1·min-1 of area under the concen- tration-time curve (AUC). Side effects and quality of life were observed before and after the chemo- therapy. Myelosuppression was severe and commonly observed. Grade 3/4 of granulocytopenia was found in 47.9% (46/96) of the patients and grade 3/4 of thrombocytopenia was noted in 28.1% (27/96) of the subjects. However, other side effects were slight. The mean score of quality of life (QOL), ac- cording to the criteria of QOL for Chinese cancer patients had reduced 6.8. At 5 mg·mL-1·min-1 by AUC, the hematological toxicity of CBP was severe and it had some negative effects on the QOL. The administration of CBP at 5 mg·mL-1·min-1 by AUC may be too high for Chinese senile patients with non-small cell lung cancer.
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| 关 键 词： | 老年人 非小细胞肺癌 化学疗法 生存质量 |
| 收稿时间： | 2007-09-26 |
Determination of carboplatin dose by area under the curve in combination chemotherapy for senile non-small cell lung cancer |
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| Yin Tiejun,Liu Qingqing,Hu Changyao,Liu Mengtao. Determination of carboplatin dose by area under the curve in combination chemotherapy for senile non-small cell lung cancer[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2007, 27(6): 710-712. DOI: 10.1007/s11596-007-0624-x |
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| Authors: | Yin Tiejun Liu Qingqing Hu Changyao Liu Mengtao |
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| Affiliation: | 1. Department of Comprehensive Medicine Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
2. Department of Oncology,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | To preliminarily determine the appropriate dosage of carboplatin (CBP) at AUC of 5 mg.Ml(-1).min(-1) in the combination chemotherapy for Chinese senile patients with non-small cell lung cancer (NSCLC). Thirty-five Chinese senile patients with NSCLC in advanced stage (III/IV) were given 96 cycles of combination chemotherapy. Chemotherapy schedules included Taxol+CBP, Gemzar+CBP and NVB+CBP. The dose of CBP was at 5 mg.mL(-1).min(-1) of area under the concentration-time curve (AUC). Side effects and quality of life were observed before and after the chemotherapy. Myelosuppression was severe and commonly observed. Grade 3/4 of granulocytopenia was found in 47.9% (46/96) of the patients and grade 3/4 of thrombocytopenia was noted in 28.1% (27/96) of the subjects. However, other side effects were slight. The mean score of quality of life (QOL), according to the criteria of QOL for Chinese cancer patients had reduced 6.8. At 5 mg.mL(-1).min(-1) by AUC, the hematological toxicity of CBP was severe and it had some negative effects on the QOL. The administration of CBP at 5 mg.mL(-1).min(-1) by AUC may be too high for Chinese senile patients with non-small cell lung cancer. |
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| Keywords: | senile patients non-small cell lung cancer carboplatin,area under the concentra-tion-time curve,quality of life |
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