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Hepatic Cell Apoptosis Was Triggerred by HBx Accumulation and Independent on Verapamil
作者姓名:王海平  陈孝平  白祥军
作者单位:DepartmentofSurgery,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China
摘    要:In order to study the roles of HBx and calcium inhibitor verapamil in apoptosis of human normal hepatic cells, L02-off, a pTet-off stably integrated human hepatic cell line was established,in which HBx expression was tightly induced by Doxycycline. The effect of different amounts of HBx and verapamil on apoptosis of human normal hepatic cells was detected. The study showed that apoptosis was triggered by accumulation of intracellular HBx, while verapamil had no effects on the apoptotic process. It was concluded that apoptosis mediated by HBx was dose-dependent but calcium-independent.

关 键 词:肝细胞凋亡  HBx积聚  异搏定  抑制剂
收稿时间:25 February 2004

Hepatic cell apoptosis was triggerred by HBx accumulation and independent on verapamil
Wang Haiping,Chen Xiaoping,Bai Xiangjun.Hepatic Cell Apoptosis Was Triggerred by HBx Accumulation and Independent on Verapamil[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(3):281-283.
Authors:Wang Haiping  Chen Xiaoping  Bai Xiangjun
Institution:Department of Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science arid Technology,Wuhan 430030,China
Abstract:Summary: In order to study the roles of HBx and calcium inhibitor verapamil in apoptosis of human normal hepatic cells, L02-off, a pTet-off stably integrated human hepatic cell line was established, in which HBx expression was tightly induced by Doxycycline. The effect of different amounts of HBx and verapamil on apoptosis of human normal hepatic cells was detected. The study showed that apoptosis was triggered by accumulation of intracellular HBx, while verapamil had no effects on the apoptotic process. It was concluded that apoptosis mediated by HBx was dose-dependent but calcium-independent.
Keywords:HBx  hepatocyte  apoptosis  calcium
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