Growth suppression of human lung cancer cells and implanted tumors by adenovirus-mediated transfer of the PTEN gene |
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| Authors: | Zhixiong Chen Jiong Yang |
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| Institution: | 1. Department of Geriatrics, People's Hospital of Wuhan University, Wuhan 430060, China
2. Department of Respiratory Medicine, People's Hospital of Wuhan University, Wuhan 430060, China |
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| Abstract: | This study examined the effects of a recombinant adenovirus Ad-PTEN-EGFP on the proliferation of A549 cells,a human lung carcinoma cell line,in vitro and on the growth of the implanted tumors in the nude mice in vivo,explored the underlying mechanisms and evaluated the in vitro transfection efficiency of Ad-PTEN-EGFP into A549 cells.The expression of Ad-PTEN-EGFP in the A549 cells was determined.The proliferation and the apoptosis rates of the A549 cells with Ad-PTEN-EGFP transfection or not was detected by... |
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| Keywords: | lung carcinoma PTEN adenovirus |
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