Cd4+ T cell apoptosis induced by anti-CD4 antibodies |
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Authors: | Zhang Zhihong Zhang Yue Zhu Huifen Yang Jing Shen Guanxin |
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Institution: | (1) Department of Immunology, Tongji Medical University, 430030 Wuhan;(2) Present address: Institute for Biomedical Photonics, School of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan |
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Abstract: | Summary To explore the inhibitory effects of anti-CD4 human/murine chimeric antibodies on lymphocyte proliferation, CD4+ T cell apoptosis induced by anti-CD4 antibodies was examined. Annexin-V-FITC and PI double stain method was employed to qualitatively
and quantitatively determined CD4+ T cell apoptosis induced by anti-CD4 antibodies. Our results showed that anti-CD4 chimeric antibodies could specifically
induce CD4+ T cell apoptosis. The ability of anti-CD4 chimeric antibodies to induce CD4+ T cell apoptosis was related with the presence of monocytes. It is concluded that the further cross-linking of anti-CD4 antibodies
is important for inducing CD4+ T cell apoptosis.
This project was supported by grant from the National Sciences Foundation of China (No. 39370628). |
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Keywords: | human/murine chimeric antibodies CD4+ T cells apoptosis |
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