Myosin-induced autoimmune myocarditis in BALB/C mice |
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Authors: | Wang Zhaohui Liao Yuhua Dong Jihua Li Shuli Wang Jinping Tu Yuanshu |
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Institution: | (1) Institute of Cardiovascular Diseases, Tongji Medical University, 430022 Wuhan |
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Abstract: | Summary Experimental mice were immunized with cardiac myosin and complete Freund’s adjuvant (CFA) on days 0, 7 and 30 and control
mice were immunized with CFA. Sera and myocardium samples were harvested on days 15, 21 and 120 after the first immunization.
Pathological findings demonstrated that there were necrosis and inflammatory infiltration in acute stage and fibrosis mainly
in chronic stage of experimental group. Anti-myosin antibodies were also found in sera of experimental mice, but not in control
group. Our study showed that cardiac myosin served as an autoantigen to provoke autoimmunity and lead to the transformation
of VMC into DCM. |
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Keywords: | myosin autoimmunity myocarditis myocardial fibrosis |
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