Analysis of the biocompatibility of magnetic porous tricalcium phosphate ceramics in rat femurs |
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Authors: | Wu Hua Zhu Tong-bo Du Jing-yuan Hong Guang-xiang Sun Shu-zhen Xu Xiao-hong |
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Institution: | (1) Department of Orthopedics, Xiehe Hospital, Tongji Medical University, Wuhan;(2) Wuhan Industrial University, Wuhan |
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Abstract: | Summary A new biomaterial, magnetic porous tricalcium phosphate ceramics (MPTCP), may be used for repairing defects in bones as a
substitute for bone grafting. This study was designed to examine its biocompatibility and the systemic toxicity. The ceramic
sections, approximately 15.3 mg, were implanted into both proximal femurs of 10 male and 10 female albino SW rats. An equal
number of male and female animals served as sham-operated controls. Implantation of MPTCP ceramics in rat femurs had no deleterious
effects on body weight, organ/body weight ratio, and on blood, liver and kidney functions. Plasma levels of inorganic phosphorus
were significantly elevated in rats implanted with MPTCP ceramics. Alkaline phosphatase values in plasma in the experimental
group were equal to those in the control group. Photomicrographs, radiographs and scanning electron photomicrographs of the
rat femurs implanted with MPTCP ceramics demonstrated excellent bone association with implants and growth of some new bone
into MPTCP ceramics. In conclusion, MPTCP ceramics are biocompatible and suitable for the reconstruction of bones. |
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Keywords: | magnetic ceramics tricalcium phosphate biocompatibility |
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