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Protective Effects of Ciliary Neurotrophic Factor on Denervated Skeletal Muscle
作者姓名:黄仕龙  王发斌  洪光祥  万圣祥  康皓
作者单位:HUANG Shilong,WANG Fabin,HONG Guangxiang,WAN Shengxiang,KANG Hao Department of Hand Surgery,Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022
摘    要:Summary: To study the effects of ciliary neurotrophic factor (CNTF) on denervated skeletal muscle atrophy and to find a new approach to ameliorate atrophy of denervated muscle, a model was estab lished by cutting the right sciatic nerve in 36 Wistar mice, with the left side serving as control. Then they were divided into two groups randomly. CNTF (1 U/ml) 0. 1 ml was injected into the right tib-ial muscle every day in experimental group, and saline was used into another group for comparison.The muscle wet weight, muscle total protein, Ca2 , physiological response and morphology were an alyzed on the 7th, 14th and 28th day after operation. Our results showed that compared to control group, there was a significant increase in muscle wet weight, total protein, Ca2 , muscle fiber cross section area in CNTF group (P< 0. 05). CNTF could ameliorate the decrease of tetanic tension (PO), post-tetanic twitch potentiation (PTP), and the prolonged muscle relaxation time (RT)caused by denervation (P<0. 05). The motor end-plate areas 7 days and 14 days after denervation was similar (P>0. 05), but significantly larger 28 days after the denervation (P<0.05). Our re-sults suggest that CNTF exerts myotrophic effects by attenuating the morphological and functional changes associated with denervation of rat muscles and has protective effects on denervated muscle and motor end plate.

收稿时间:12 December 2001

Protective effects of ciliary neurotrophic factor on denervated skeletal muscle
Huang Shilong,Wang Fabin,Hong Guangxiang,Wan Shengxiang,Kang Hao.Protective Effects of Ciliary Neurotrophic Factor on Denervated Skeletal Muscle[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2002,22(2):148-151.
Authors:Huang Shilong  Wang Fabin  Hong Guangxiang  Wan Shengxiang  Kang Hao
Institution:Department of Hand Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022
Abstract:Summary: To study the effects of ciliary neurotrophic factor (CNTF) on denervated skeletal muscle atrophy and to find a new approach to ameliorate atrophy of denervated muscle, a model was established by cutting the right sciatic nerve in 36 Wistar mice, with the left side serving as control. Then they were divided into two groups randomly. CNTF (1 U/ml) 0.1 ml was injected into the right tibial muscle every day in experimental group, and saline was used into another group for comparison. The muscle wet weight, muscle total protein, Ca 2+, physiological response and morphology were analyzed on the 7th, 14th and 28th day after operation. Our results showed that compared to control group, there was a significant increase in muscle wet weight, total protein, Ca 2+, muscle fiber cross-section area in CNTF group (P<0.05). CNTF could ameliorate the decrease of tetanic tension (PO), post-tetanic twitch potentiation (PTP), and the prolonged muscle relaxation time (RT) caused by denervation (P<0.05). The motor end-plate areas 7 days and 14 days after denervation was similar (P>0.05), but significantly larger 28 days after the denervation (P<0.05). Our results suggest that CNTF exerts myotrophic effects by attenuating the morphological and functional changes associated with denervation of rat muscles and has protective effects on denervated muscle and motor end plate.
Keywords:peripheral nerve skeletal muscle atrophy
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