| Effects of Cimetidine on IL－2 and T Suppressor Cell Function in Rats with Obstructive Jaundice |
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| 引用本文： | 丁显仲,李桦,熊叔陶,张寿熙,吕坤章,邵静芳,沈关心,杨静.Effects of Cimetidine on IL－2 and T Suppressor Cell Function in Rats with Obstructive Jaundice[J].华中科技大学学报(医学英德文版),1994,14(2):94-97. |
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| 作者姓名： | 丁显仲 李桦 熊叔陶 张寿熙 吕坤章 邵静芳 沈关心 杨静 |
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| 作者单位： | DING Xian-zhong; LI Hua; XIONG Shu-tao;ZHANG Shou-xi; LU Kun-zhang(Deparlment of General Surgery，Xiehe Hospilal，Tongji Medical University，Wuhan)SHAO Jing-fang; SHEN Guan-xin; YANG Jing(Department of Immunology，Tongji Medical University，Wuhan) |
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| 摘 要： | ＥｆｆｅｃｔｓｏｆＣｉｍｅｔｉｄｉｎｅｏｎＩＬ－２ａｎｄＴＳｕｐｐｒｅｓｓｏｒＣｅｌｌＦｕｎｃｔｉｏｎｉｎＲａｔｓｗｉｔｈＯｂｓｔｒｕｃｔｉｖｅＪａｕｎｄｉｃｅＤＩＮＧＸｉａｎ－ｚｈｏｎｇ（丁显仲）；ＬＩＨｕａ（李桦）；ＸＩＯＮＧＳｈｕ－ｔａｏ（熊叔...
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| 收稿时间： | 1 December 1993 |
Effects of cimetidine on IL-2 and T suppressor cell function in rats with obstructive jaundice |
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| Ding Xian-zhong,Li Hua,Xiong Shu-tao,Zhang Shou-xi,Lu Kun-zhang,Shao Jing-fang,Shen Guan-xin,Yang Jing.Effects of cimetidine on IL-2 and T suppressor cell function in rats with obstructive jaundice[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1994,14(2):94-97. |
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| Authors: | Ding Xian-zhong Li Hua Xiong Shu-tao Zhang Shou-xi Lu Kun-zhang Shao Jing-fang Shen Guan-xin Yang Jing |
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| Institution: | (1) Department of General Surgery, Xiehe Hospital, Tongji Medical University, Wuhan;(2) Department of Immunology, Tongji Medical University, Wuhan |
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| Abstract: | Summary Susceptibility to infection in patients with obstructive jaundice is much more higher than non-jaundiced patients. The reasons
for this are not completely understood. It is postulated that this may have some relation to changes of patients’ immune function.
This article reported the changes of splenocyte IL-2 production and T Suppressor cell activity in rats with obstructive jaundice.
Meanwhile, we also investigated effects of cimetidine on immune function in rats with bile duct ligation. The results show
that IL-2 production in obstructive jaundiced rats significantly decreased and T suppressor cell activity markably increased.
Cimetidine could remarkably enhance IL-2 production and suppress T Suppressor cell activity. Abmormaility of immune function
may be one reason for high susceptibility to infection in patients with obstructive jaundice in perioperative period. Cimetidine,
which could clearly improve immune function in rats with obstructive jaundice, might be a valuable agent for strengthening
the capacity of fighting infection in patients with obstructive jaundice. |
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| Keywords: | obstructive jaundice interleukin 2 T suppressor cell cimetidine immunoregulation |
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