Preparation of adriamycin magnetic albumin microspheres and their experimental antitumor effectsin vitro andin vivo |
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Authors: | Tao Kaixiong Chen Daoda Chen Jianying Tian Yuan Wu Zaide Wang Xiansong Yang Xiuping |
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Institution: | (1) Department of General Surgery, Xiehe Hospital, Tongji Medical University, 430022 Wuhan |
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Abstract: | Summary The adriamycin magnetic microspheres (ADM-MAMs) were prepared by the heat-stabilized protein methods. Their physico-chemical
properties were examined; their cytotoxicities against tumor cellsin vitro were assayed by a modified MTT method, and their effects were observed on the implanted gastric tumor in Wistar rats given
ADM-MAMs via alimentary canal at the presence of the external magnetic fields. The results showed that the ADM-MAMs were successfully
prepared and had cytotoxic effect on tumor cellsin vitro similar to the free ADM (P>0. 05). The inhibitory effects of ADM-MAMs on the implanted gastric tumorin vivo were significantly increased as compared with the controls (P<0. 01). Our results suggested that ADM-MAMs were a new type of adriamycin (ADM) preparation and its form alteration did not
affect its anticancer effects.
This Project was supported by a grant from foundation of “Ninth-five Plan” National Key Medical Scientific and Technic Special
Subjects of China (No. 969060116). |
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Keywords: | adriamycin magnetic microsphere preparation cytotoxicity implanted gastric tumor magnetic field |
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