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Preparation of adriamycin magnetic albumin microspheres and their experimental antitumor effectsin vitro andin vivo
Authors:Tao Kaixiong  Chen Daoda  Chen Jianying  Tian Yuan  Wu Zaide  Wang Xiansong  Yang Xiuping
Institution:(1) Department of General Surgery, Xiehe Hospital, Tongji Medical University, 430022 Wuhan
Abstract:Summary The adriamycin magnetic microspheres (ADM-MAMs) were prepared by the heat-stabilized protein methods. Their physico-chemical properties were examined; their cytotoxicities against tumor cellsin vitro were assayed by a modified MTT method, and their effects were observed on the implanted gastric tumor in Wistar rats given ADM-MAMs via alimentary canal at the presence of the external magnetic fields. The results showed that the ADM-MAMs were successfully prepared and had cytotoxic effect on tumor cellsin vitro similar to the free ADM (P>0. 05). The inhibitory effects of ADM-MAMs on the implanted gastric tumorin vivo were significantly increased as compared with the controls (P<0. 01). Our results suggested that ADM-MAMs were a new type of adriamycin (ADM) preparation and its form alteration did not affect its anticancer effects. This Project was supported by a grant from foundation of “Ninth-five Plan” National Key Medical Scientific and Technic Special Subjects of China (No. 969060116).
Keywords:adriamycin  magnetic microsphere  preparation  cytotoxicity  implanted gastric tumor  magnetic field
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