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| Effect of Icariin on Cyclic GMP Levels and on the mRNA Expression of cGMP-binding cGMP-specific Phosphodiesterase (PDE5) in Penile Cavernosum | |
| 作者姓名： | 蒋兆健 胡本容 王嘉陵 汤强 谭艳 向继洲 刘菊妍 |
| 摘 要： | Penile erection, which is characterized by the relaxation of arterial and cavernous smooth muscles, is mediated by nitric oxide (NO). After its release from endothelial cells and nerve endings within the penis, NO diffuses into the smooth muscle cells and activates the soluble guanyl cyclase, which then catalyzes the conversion of GTP to cGMP1, 2]. Elevated cGMP concentrations activate pro- tein kinase G (PKG), which in turn phosphorylates gap junctions, potassium (K ) channels, and ca… |
| 收稿时间： | 12 March 2006 |
Effect of Icariin on Cyclic GMP Levels and on the mRNA Expression of cGMP-binding cGMP-specific Phosphodiesterase (PDE5) in Penile Cavernosum |
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| JIANG Zhaojian,HU Benrong,WANG Jialing,TANG Qiang,TAN Yan,XIANG Jizhou,LIU Juyan.Effect of Icariin on Cyclic GMP Levels and on the mRNA Expression of cGMP-binding cGMP-specific Phosphodiesterase (PDE5) in Penile Cavernosum[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(4):460-462. | |
| Authors: | JIANG Zhaojian HU Benrong WANG Jialing TANG Qiang TAN Yan XIANG Jizhou LIU Juyan |
| Institution: | 1. Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Guangzhou Hanfang Natural Medicine Research & Development Co., Ltd Guangzhou 510240 2. Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 3. Guangzhou Hanfang Natural Medicine Research & Development Co., Ltd Guangzhou 510240 |
| Abstract: | |
| Keywords: | penis erectile dysfunction icariin nitric oxide phosphodiesterase type 5 |
| 本文献已被 万方数据 SpringerLink 等数据库收录！ | |