| Effects of 3，4－Dihydroxyacetophenone on Hypoxic Vasoconstriction in Isolated Pulmonary and Basilar Arterial Rings |
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| 引用本文： | 王迪浔,邓洁.Effects of 3，4－Dihydroxyacetophenone on Hypoxic Vasoconstriction in Isolated Pulmonary and Basilar Arterial Rings[J].华中科技大学学报(医学英德文版),1994,14(4):252-256. |
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| 作者姓名： | 王迪浔 邓洁 |
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| 作者单位： | Department of Pathophysiology，Tongji Medical University，Wuhan |
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| 摘 要： | Ｅｆｆｅｃｔｓｏｆ３，４－ＤｉｈｙｄｒｏｘｙａｃｅｔｏｐｈｅｎｏｎｅｏｎＨｙｐｏｘｉｃＶａｓｏｃｏｎｓｔｒｉｃｔｉｏｎｉｎＩｓｏｌａｔｅｄＰｕｌｍｏｎａｒｙａｎｄＢａｓｉｌａｒＡｒｔｅｒｉａｌＲｉｎｇｓＦａｒｍａｎＵｌｌａｈ，ＷａｎｇＤｉ－ｘｕｎ（王...
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| 收稿时间： | 31 October 1994 |
Effects of 3, 4-Dihydroxyacetophenone on hypoxic vasoconstriction in isolated pulmonary and basilar arterial rings |
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| Farman Ullah,Wang Di-xun,Deng Jie.Effects of 3, 4-Dihydroxyacetophenone on hypoxic vasoconstriction in isolated pulmonary and basilar arterial rings[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1994,14(4):252-256. |
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| Authors: | Farman Ullah Wang Di-xun Deng Jie |
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| Institution: | (1) Department of Pathophysiology, Tongji Medical University, Wuhan |
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| Abstract: | Summary The effects of 3, 4-DHAP on hypoxic vasoconstriction response in pulmonary (PA) and basilar arterial (BA) rings of rabbits
and their mechanism were compared in vitro.
3,4-DHAP in different concentration (2. 64 × 10-4,7. 92 × 10-4,2. 376 × 10-3 mol/L) decreased the basal tone of PA rings by 32. 39 ± 9. 4 mg, 68. 96± 26. 54 mg and 145. 60 ± 58. 07 mg respectively,
while the tension of the BA rings was decreased by 13. 80 ±5. 08 mg, 17.18 ± 3. 36 mg and 25. 00 ± 4. 02 mg respectively.
In PA rings it also decreased the percentage increase in tension induced by hypoxia (TIH%) from the control value 48.82 ±
5.75% to 10.02 ± 3.62%, 2. 14 ± 0.96%, and 0. 00 % respectively, while in BA rings from 27. 27 ± 5.78% to 11. 23 ± 2.71%,
7.49 ± 1.62%, and 1.45 ± 1.13% respectively. The effects of 3, 4-DHAP on TIH% were partially blocked by indomethacin 10 M
and L-NAME 10 M.
The results showed that 3, 4-DHAP can decrease the hypoxic pulmonary and basilar vasoconstriction in vitro, which can be partially
inhibited by cyclooxygenase inhibitor and NO/EDRF inhibitor. |
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| Keywords: | pulmonary artery basilar artery hypoxia 3 4 Dihydroxyacetophenone |
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