|
|||||
|
|
| Growth-inhibitory Effects of Curcumin on Ovary Cancer Cells and Its Mechanisms | |
| 作者姓名： | 郑丽端 童强松 吴翠环 |
| 作者单位： | Department of Pathology，Department of Pediatric Surgery，Department of Pathology Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022 |
| 摘 要： | Sinceanti carcinogenicagentsalsobringabouttheapoptosisinnormalcellswhiletheyinduceapop tosisinneoplasmcells ,inrecent years ,efforthasbeendirectedatlookingforneweffectiveanti cancerdrugswithlowtoxicity .Curcuministhemajoractivecomponentofcurcuma ,whichisa… |
| 关 键 词： | 卵巢癌 肿瘤抑制 姜黄色素 细胞凋亡 MTT法 组织形态学 |
| 收稿时间： | 16 September 2002 |
Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms |
|
| Zheng Liduan,Tong Qiangsong,Wu Cuihuan.Growth-inhibitory Effects of Curcumin on Ovary Cancer Cells and Its Mechanisms[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(1):55-58. | |
| Authors: | Zheng Liduan Tong Qiangsong Wu Cuihuan |
| Institution: | 1. Department of Pathology,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022 2. Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 3. Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 |
| Abstract: | Summary To study the growth-inhibitory effects of curcumin on human ovary cancer A2780 cellsin vitro and its molecular mechanisms, the growth inhibition rates of A2780 cancer cells, after being treated with 10 μmol/L–50 μmol/L curcumin for 6–24 h, were examined by MTT method. The morphological changes of cancer cells were observed under inversion microscopy. Cellular apoptotic rates were determined by using TUNEL. The protein expression levels of bcl-2, p53 and MDM2 in cancer cells were examined by SP immunohistochemistry. After being treated by various concentrations of curcumin, the growth of cancer cells was inhibited significantly. Some cancer cells presented characteristic morphological changes of apoptosis. The rates of apoptosis were 6.41%–28.48% (P<0.01). The expression of bcl-2 and p53 was decreased, which depended on the action time (P<0.01). There were no obvious changes in MDM2 expression. It was concluded that curcumin could significantly inhibit the growth of ovary cancer cells. The induction of apoptosis by down-regulating the expression of bcl-2 and p53 was probably one of its molecular mechanisms. ZHENG Liduan, female, born in 1973, Doctor in Charge |
| Keywords: | curcumin ovary cancer gene expression apoptosis |
| 本文献已被 CNKI 万方数据 SpringerLink 等数据库收录！ | |