| Changes of Regulatory T Cells in Graves＇ Disease |
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| 引用本文： | 王红祥,赵湜,唐晓琼,李菁媛,邹萍.Changes of Regulatory T Cells in Graves＇ Disease[J].华中科技大学学报(医学英德文版),2006,26(5):545-547. |
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| 作者姓名： | 王红祥 赵湜 唐晓琼 李菁媛 邹萍 |
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| 作者单位： | WANG Hongxiang ZHAO Shi TANG Xiaoqiong，LI Jingyuan，ZOU Ping |
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| 摘 要： | The immune mechanism of Graves＇ diseases （GD） and the roles of regulator T cells were investigated. In 32 patients with GD （GD group） and 20 healthy volunteers （control group）, flow cytometry was used to detect the proportion of CD4^＋CD25^＋ cells, MACS to isolate CD4^＋ CD25^＋ cells, RT-PCR to assay the expression of FOXP3, and ELISA to test the leyel of IL-10, respectively. It was found that there was no significant change in the proportion of CD4^＋CD25^＋ T cells between GD group and control group （P〉0.05）, while secretion of IL-10 and expression of FOXP3 in GD group were lower than control group （P〈0.01 and P〈0.05, respectively）. In conclusion, though the proportion of regulatory T cells of peripheral blood lymphocytes in the patients with GD, the functions of them were significantly weakened, which might be a pathogenic factor in GD.
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| 关 键 词： | T细胞 病理 治疗 综合征 |
| 收稿时间： | 2005-04-25 |
Changes of regulatory T cells in Graves’ disease |
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| Hongxiang Wang,Shi Zhao,Xiaoqiong Tang,Jingyuan Li,Ping Zou.Changes of regulatory T cells in Graves’ disease[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(5):545-547. |
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| Authors: | Hongxiang Wang Shi Zhao Xiaoqiong Tang Jingyuan Li Ping Zou |
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| Abstract: | The immune mechanism of Graves' diseases (GD) and the roles of regulator T cells were investigated. In 32 patients with GD (GD group) and 20 healthy volunteers (control group), flow cy-tometry was used to detect the proportion of CD4 CD25 cells, MACS to isolate CD4 CD25 cells, RT-PCR to assay the expression of FOXP3, and ELISA to test the level of IL-10, respectively. It was found that there was no significant change in the proportion of CD4 CD25 T cells between GD group and control group (P>0.05), while secretion of IL-10 and expression of FOXP3 in GD group were lower than control group (P<0.01 and P<0.05, respectively). In conclusion, though the proportion of regulatory T cells of peripheral blood lymphocytes in the patients with GD, the functions of them were significantly weakened, which might be a pathogenic factor in GD. |
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| Keywords: | Graves' disease regulatory T cell IL-10 FOXP3 |
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