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Comparative Potency of Seven Compounds Isolated from TripterygiumWilfordii on Cultred Rat Leydig Cells and Sertoli Cells
作者姓名:兰子鉴  庄临之  徐阳  秦国伟  徐任生  顾芝萍
作者单位:[1]ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences,Shanghai,200031,China [2]StateKeyLaboratoryofReproductiveBiology,InstituteofZoology,ChineseAcade-myofSciences,Bejing,100080,China
摘    要:The damaging effect of seven compounds isolated from Triptervgium Witfordii Hook. F, were tested on the rat Leydig cells and Sertoli cells in culture. The results showed that 10μg/ ml orthosphenic acid (TW2), 10μg/ ml 3β,22α-dihydroxy-△^12 ursen-30-oic acid(TW5), 5.0 μg/ ml 3β,22α -dihydroxy-△^12-oleanen-29-oieaeid(TW6), 5.0μg/ ml salaspermic acid(TW7), 0.5μg/ mt eelastrol(TW27) and 1.25μg/ml polpunonic acid (TW28) were all detrimental to Leydig cells and Sertoti eells. However, 30μg/ ml wilJbrlideA (TW1) did not affect the viability of Leydig cells and Sertoli cells significantly. The most toxic compounds was TW27, and the least, TW1. These results suggested that the -COOH at the C-20 site of these triterpenoids mat, be tbe funetional chemical group responsible for the damaging effect on the Leydig cells and Sertoli cells.

关 键 词:雷公藤  化合物  塞尔托利细胞  莱迪希氏细胞  老鼠  破坏作用  生育能力

Comparative Potency of Seven Compounds Isolated from Tripterygium Wilfordii on Cultred Rat Leydig Cells and Sertoli Cells
Lan Zi-jian,Zhuang Lin-zhi,Xu Yang,Qin Guo-wei,Xu Ren-sheng and Gu Zhi-ping.Comparative Potency of Seven Compounds Isolated from TripterygiumWilfordii on Cultred Rat Leydig Cells and Sertoli Cells[J].Journal of Reproduction and Contraception,1994,5(1):197-203.
Authors:Lan Zi-jian  Zhuang Lin-zhi  Xu Yang  Qin Guo-wei  Xu Ren-sheng and Gu Zhi-ping
Abstract:
Keywords:Tripterygium Wilfordii  Leydig cells  Sertoli cells
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