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口服葡萄糖耐量试验1h血糖升高体检者胰岛β细胞功能的观察
引用本文:关静,杨瑛,刘献成,贺彩霞,金小桦.口服葡萄糖耐量试验1h血糖升高体检者胰岛β细胞功能的观察[J].中华全科医师杂志,2011,10(11):827-829.
作者姓名:关静  杨瑛  刘献成  贺彩霞  金小桦
作者单位:1. 266034,青岛阜外心血管病医院特需科
2. 青岛市立医院特需科
3. 266034,青岛阜外心血管病医院内科
摘    要:对793例健康体检者行口服葡萄糖耐量试验(OGTT),根据受试者工作特征曲线确定糖负荷1h血糖升高切割点,分为OGTT 1h血糖正常583例(NGTN组)、OGTT 1h血糖升高127例(NGT1H组)、葡萄糖耐量减低83例(IGT组),比较各组间的代谢指标及稳态模型胰岛素抵抗指数(HOMA—IR)、胰岛β细胞功能指数(HOMA-β)和胰岛素生成指数(IGI)。NGT1H组体重指数、腰围、甘油三酯、空腹血糖高于NGTN组,高密度脂蛋白胆固醇低于NGTN组;NGT1H组的HOMA—β(4.5±0.7)和IGI(2.1±0.7)水平低于NGTN组(4.8±0.7,2.7±0.9),HOMA—IR(1.2±0.6)高于NGTN组(0.5±0.6),NGT1H组HOMA—β水平高于IGT组(4.4±0.6),差异有统计学意义(P〈0.05)。提示OGTT 1h血糖升高也是机体糖代谢受损的指标,存在胰岛素早时相分泌异常和胰岛素抵抗。

关 键 词:葡萄糖代谢障碍  胰岛β细胞功能

β-cell function of subjects with 1-hour hyperglycemia in oral glucose tolerance test
GUAN Jing,YANG Ying,LIU Xian-cheng,HE Cai-xia,JIN Xiao-hua.β-cell function of subjects with 1-hour hyperglycemia in oral glucose tolerance test[J].Chinese JOurnal of General Practitioners,2011,10(11):827-829.
Authors:GUAN Jing  YANG Ying  LIU Xian-cheng  HE Cai-xia  JIN Xiao-hua
Institution:. (Department of VIP Service, Fuwai Cardiology Hospital in Qingdao ,266034 ,Shandong, China)
Abstract:Based on the results of oral glucose tolerance test( OGTT )and the levels of 1-h plasma glucose ( 1 hPG),793 subjects were classified into three groups:583 with NGTN ( normal 1 hPG in OGTT),127 with NGT1 H( higher 1 hPG in OGTT) and 83 with IGT( impaired glucose tolerance).NGT1H group had large waist circumference,higher body mass index,fasting plasma glucose( FPG),triglyceride,and lower high density lipoprotein-cholesterol than those of NGTN group.NGT1 H group had higher homeostasis model assessment insulin index ( 1.2 ± 0.6),lower homeostasis model assessment β3 ( HOMA-β ) (4.5 ± 0.7 ) and insulinogenic index (2.1 ±0.7) than those of NGTN group(0.5 ±0.6,4.8 ±0.7,2.7 ±0.9,respectively,all P <0.05 ).HOMA-β of NGT1 H group was higher than that of IGT group(4.5 ±0.7 vs.4.4 ±0.6,P <0.05 ).The results indicate that 1 hPG in OGTT may identify a condition of glucose metabolic abnormalities characterized by insulin resistance and reduced β-cell function.
Keywords:Glucose metabolism disorders  pancreatic β-cell function
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